|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 33206 |
FusionGeneSummary for SENP5_PIGZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SENP5_PIGZ | Fusion gene ID: 33206 | Hgene | Tgene | Gene symbol | SENP5 | PIGZ | Gene ID | 205564 | 80235 |
| Gene name | SUMO specific peptidase 5 | phosphatidylinositol glycan anchor biosynthesis class Z | |
| Synonyms | - | GPI-MT-IV|PIG-Z|SMP3 | |
| Cytomap | 3q29 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sentrin-specific protease 5SUMO1/sentrin specific peptidase 5SUMO1/sentrin specific protease 5sentrin/SUMO-specific protease SENP5 | GPI mannosyltransferase 4GPI mannosyltransferase IVSMP3 mannosyltransferasedol-P-Man dependent GPI mannosyltransferasephosphatidylinositol glycan, class Zphosphatidylinositol-glycan biosynthesis class Z protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96HI0 | Q86VD9 | |
| Ensembl transtripts involved in fusion gene | ENST00000445299, ENST00000323460, ENST00000419026, ENST00000489744, | ENST00000412723, ENST00000443835, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SENP5 [Title/Abstract] AND PIGZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A129-01A | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000445299 | ENST00000412723 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| Frame-shift | ENST00000445299 | ENST00000443835 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| Frame-shift | ENST00000323460 | ENST00000412723 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| Frame-shift | ENST00000323460 | ENST00000443835 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| intron-3CDS | ENST00000419026 | ENST00000412723 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| intron-3CDS | ENST00000419026 | ENST00000443835 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| intron-3CDS | ENST00000489744 | ENST00000412723 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
| intron-3CDS | ENST00000489744 | ENST00000443835 | SENP5 | chr3 | 196613565 | + | PIGZ | chr3 | 196678902 | - |
Top |
FusionProtFeatures for SENP5_PIGZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SENP5 | PIGZ |