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Fusion gene ID: 33201

FusionGeneSummary for SENP5_FAM193A

Fusion gene summary

Fusion gene information	Fusion gene name: SENP5_FAM193A
	Fusion gene ID: 33201
		Hgene	Tgene
	Gene symbol	SENP5	FAM193A
	Gene ID	205564	8603
	Gene name	SUMO specific peptidase 5	family with sequence similarity 193 member A
	Synonyms	-	C4orf8\|RES4-22
	Cytomap	3q29	4p16.3
	Type of gene	protein-coding	protein-coding
	Description	sentrin-specific protease 5SUMO1/sentrin specific peptidase 5SUMO1/sentrin specific protease 5sentrin/SUMO-specific protease SENP5	protein FAM193A
	Modification date	20180523	20180519
	UniProtAcc	Q96HI0	P78312
	Ensembl transtripts involved in fusion gene	ENST00000445299, ENST00000323460, ENST00000419026, ENST00000489744,	ENST00000545951, ENST00000382839, ENST00000324666, ENST00000502458, ENST00000505311,
Fusion gene scores	* DoF score	8 X 6 X 7=336	5 X 4 X 5=100
	# samples	9	6
	** MAII score	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SENP5 [Title/Abstract] AND FAM193A [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SARC	TCGA-DX-AB2Z-01A	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000445299	ENST00000545951	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000445299	ENST00000382839	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000445299	ENST00000324666	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000445299	ENST00000502458	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000445299	ENST00000505311	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000323460	ENST00000545951	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000323460	ENST00000382839	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000323460	ENST00000324666	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000323460	ENST00000502458	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000323460	ENST00000505311	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000419026	ENST00000545951	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000419026	ENST00000382839	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000419026	ENST00000324666	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000419026	ENST00000502458	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
Frame-shift	ENST00000419026	ENST00000505311	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
intron-3CDS	ENST00000489744	ENST00000545951	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
intron-3CDS	ENST00000489744	ENST00000382839	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
intron-3CDS	ENST00000489744	ENST00000324666	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
intron-3CDS	ENST00000489744	ENST00000502458	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+
intron-3CDS	ENST00000489744	ENST00000505311	SENP5	chr3	196657771	+	FAM193A	chr4	2673848	+

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FusionProtFeatures for SENP5_FAM193A

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SENP5 Q96HI0	FAM193A P78312

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Fusion gene ID: 33201

FusionGeneSummary for SENP5_FAM193A

FusionProtFeatures for SENP5_FAM193A