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Fusion gene ID: 33197 |
FusionGeneSummary for SENP3_ARHGAP27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SENP3_ARHGAP27 | Fusion gene ID: 33197 | Hgene | Tgene | Gene symbol | SENP3 | ARHGAP27 | Gene ID | 26168 | 201176 |
| Gene name | SUMO specific peptidase 3 | Rho GTPase activating protein 27 | |
| Synonyms | SMT3IP1|SSP3|Ulp1 | CAMGAP1|PP905|SH3D20|SH3P20 | |
| Cytomap | 17p13.1 | 17q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sentrin-specific protease 3SUMO-1-specific protease 3SUMO1/sentrin/SMT3 specific peptidase 3sentrin/SUMO-specific protease 3 | rho GTPase-activating protein 27CIN85-associated multi-domain-containing Rho GTPase-activating protein 1SH3 domain containing 20SH3 domain-containing protein 20rho-type GTPase-activating protein 27 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H4L4 | Q6ZUM4 | |
| Ensembl transtripts involved in fusion gene | ENST00000578868, ENST00000321337, ENST00000429205, | ENST00000532038, ENST00000376922, ENST00000528384, ENST00000455881, ENST00000532891, ENST00000428638, ENST00000442348, ENST00000582826, ENST00000528273, ENST00000290470, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 3 X 2=18 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/18*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SENP3 [Title/Abstract] AND ARHGAP27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A6YQ-01A | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000578868 | ENST00000532038 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000578868 | ENST00000376922 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000578868 | ENST00000528384 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000578868 | ENST00000455881 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000578868 | ENST00000532891 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000578868 | ENST00000428638 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000578868 | ENST00000442348 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000578868 | ENST00000582826 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000578868 | ENST00000528273 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000578868 | ENST00000290470 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000321337 | ENST00000532038 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000321337 | ENST00000376922 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000321337 | ENST00000528384 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000321337 | ENST00000455881 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000321337 | ENST00000532891 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000321337 | ENST00000428638 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000321337 | ENST00000442348 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000321337 | ENST00000582826 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000321337 | ENST00000528273 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000321337 | ENST00000290470 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000429205 | ENST00000532038 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000429205 | ENST00000376922 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-3UTR | ENST00000429205 | ENST00000528384 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000429205 | ENST00000455881 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000429205 | ENST00000532891 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000429205 | ENST00000428638 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000429205 | ENST00000442348 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000429205 | ENST00000582826 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000429205 | ENST00000528273 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
| 3UTR-intron | ENST00000429205 | ENST00000290470 | SENP3 | chr17 | 7474967 | + | ARHGAP27 | chr17 | 43472567 | - |
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FusionProtFeatures for SENP3_ARHGAP27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SENP3 | ARHGAP27 |