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Fusion gene ID: 33187 |
FusionGeneSummary for SENP2_ABR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SENP2_ABR | Fusion gene ID: 33187 | Hgene | Tgene | Gene symbol | SENP2 | ABR | Gene ID | 59343 | 29 |
| Gene name | SUMO specific peptidase 2 | ABR, RhoGEF and GTPase activating protein | |
| Synonyms | AXAM2|SMT3IP2 | MDB | |
| Cytomap | 3q27.2 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2 | active breakpoint cluster region-related proteinactive BCR-related | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HC62 | Q12979 | |
| Ensembl transtripts involved in fusion gene | ENST00000545472, ENST00000296257, ENST00000427465, ENST00000465201, | ENST00000302538, ENST00000544583, ENST00000572441, ENST00000574437, ENST00000291107, ENST00000543210, ENST00000536794, ENST00000573895, | |
| Fusion gene scores | * DoF score | 8 X 6 X 8=384 | 14 X 13 X 8=1456 |
| # samples | 9 | 18 | |
| ** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1456*10)=-3.01594154386902 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SENP2 [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SENP2 | GO:0016926 | protein desumoylation | 20194620 |
| Hgene | SENP2 | GO:0031397 | negative regulation of protein ubiquitination | 22028379 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-A6B2-01A | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000545472 | ENST00000302538 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000545472 | ENST00000544583 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000545472 | ENST00000572441 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000545472 | ENST00000574437 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000545472 | ENST00000291107 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000545472 | ENST00000543210 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000545472 | ENST00000536794 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5CDS-intron | ENST00000545472 | ENST00000573895 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000296257 | ENST00000302538 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000296257 | ENST00000544583 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000296257 | ENST00000572441 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000296257 | ENST00000574437 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000296257 | ENST00000291107 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000296257 | ENST00000543210 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| Frame-shift | ENST00000296257 | ENST00000536794 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5CDS-intron | ENST00000296257 | ENST00000573895 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000302538 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000544583 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000572441 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000574437 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000291107 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000543210 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000536794 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 5UTR-intron | ENST00000427465 | ENST00000573895 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-3CDS | ENST00000465201 | ENST00000302538 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-3CDS | ENST00000465201 | ENST00000544583 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-3CDS | ENST00000465201 | ENST00000572441 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-3CDS | ENST00000465201 | ENST00000574437 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-3CDS | ENST00000465201 | ENST00000291107 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-3CDS | ENST00000465201 | ENST00000543210 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-3CDS | ENST00000465201 | ENST00000536794 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
| 3UTR-intron | ENST00000465201 | ENST00000573895 | SENP2 | chr3 | 185307957 | + | ABR | chr17 | 915225 | - |
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FusionProtFeatures for SENP2_ABR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SENP2 | ABR |