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Fusion gene ID: 33146 |
FusionGeneSummary for SEMA3F_SLC9A9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEMA3F_SLC9A9 | Fusion gene ID: 33146 | Hgene | Tgene | Gene symbol | SEMA3F | SLC9A9 | Gene ID | 6405 | 285195 |
| Gene name | semaphorin 3F | solute carrier family 9 member A9 | |
| Synonyms | SEMA-IV|SEMA4|SEMAK | AUTS16|NHE9 | |
| Cytomap | 3p21.31 | 3q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | semaphorin-3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3Fsemaphorin III/Fsemaphorin IV | sodium/hydrogen exchanger 9Na(+)/H(+) exchanger 9putative protein product of Nbla00118sodium/proton exchanger NHE9solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13275 | Q8IVB4 | |
| Ensembl transtripts involved in fusion gene | ENST00000413852, ENST00000002829, ENST00000434342, | ENST00000316549, ENST00000498717, | |
| Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 7 X 7 X 5=245 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SEMA3F [Title/Abstract] AND SLC9A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SEMA3F | GO:0007411 | axon guidance | 15814794 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-95-7039-01A | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000413852 | ENST00000316549 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
| 5UTR-intron | ENST00000413852 | ENST00000498717 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
| 5UTR-3CDS | ENST00000002829 | ENST00000316549 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
| 5UTR-intron | ENST00000002829 | ENST00000498717 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
| intron-3CDS | ENST00000434342 | ENST00000316549 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
| intron-intron | ENST00000434342 | ENST00000498717 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
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FusionProtFeatures for SEMA3F_SLC9A9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEMA3F | SLC9A9 |