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Fusion gene ID: 33135 |
FusionGeneSummary for SEMA3C_CD36 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEMA3C_CD36 | Fusion gene ID: 33135 | Hgene | Tgene | Gene symbol | SEMA3C | CD36 | Gene ID | 10512 | 948 |
| Gene name | semaphorin 3C | CD36 molecule | |
| Synonyms | SEMAE|SemE | BDPLT10|CHDS7|FAT|GP3B|GP4|GPIV|PASIV|SCARB3 | |
| Cytomap | 7q21.11 | 7q21.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | semaphorin-3Csema Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Csemaphorin E | platelet glycoprotein 4CD36 antigen (collagen type I receptor, thrombospondin receptor)CD36 molecule (thrombospondin receptor)GPIIIBPAS IVPAS-4 proteincluster determinant 36fatty acid translocaseglycoprotein IIIbleukocyte differentiation antigen | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | Q99985 | P16671 | |
| Ensembl transtripts involved in fusion gene | ENST00000265361, ENST00000544525, ENST00000419255, ENST00000536800, ENST00000487621, | ENST00000435819, ENST00000309881, ENST00000534394, ENST00000441109, ENST00000394788, ENST00000447544, ENST00000432207, ENST00000544133, ENST00000538969, ENST00000433696, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 3 X 4 X 4=48 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SEMA3C [Title/Abstract] AND CD36 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CD36 | GO:0001954 | positive regulation of cell-matrix adhesion | 17416590 |
| Tgene | CD36 | GO:0007263 | nitric oxide mediated signal transduction | 17416590 |
| Tgene | CD36 | GO:0019934 | cGMP-mediated signaling | 17416590 |
| Tgene | CD36 | GO:0044539 | long-chain fatty acid import | 17416590|22022213 |
| Tgene | CD36 | GO:0071726 | cellular response to diacyl bacterial lipopeptide | 16880211 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-GV-A3QF-01A | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| TCGA | RV | LUSC | TCGA-22-5492-01A | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265361 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| In-frame | ENST00000265361 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| In-frame | ENST00000265361 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000265361 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000265361 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000265361 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000265361 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000265361 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000265361 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000265361 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000544525 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000544525 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000544525 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000544525 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000544525 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000544525 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000544525 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000544525 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000544525 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000544525 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000419255 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000419255 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000419255 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000419255 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000419255 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000419255 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000419255 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000419255 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000419255 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000419255 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000536800 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000536800 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| Frame-shift | ENST00000536800 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000536800 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000536800 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000536800 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000536800 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000536800 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000536800 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-intron | ENST00000536800 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-3CDS | ENST00000487621 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-3CDS | ENST00000487621 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-3CDS | ENST00000487621 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-intron | ENST00000487621 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-intron | ENST00000487621 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-intron | ENST00000487621 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-intron | ENST00000487621 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-intron | ENST00000487621 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-intron | ENST00000487621 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5UTR-intron | ENST00000487621 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80293722 | + |
| 5CDS-5UTR | ENST00000265361 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000265361 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-5UTR | ENST00000544525 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000544525 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-5UTR | ENST00000419255 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000419255 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-5UTR | ENST00000536800 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5CDS-intron | ENST00000536800 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-5UTR | ENST00000487621 | ENST00000435819 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000309881 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000534394 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000441109 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000394788 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000447544 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000432207 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000544133 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000538969 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
| 5UTR-intron | ENST00000487621 | ENST00000433696 | SEMA3C | chr7 | 80545995 | - | CD36 | chr7 | 80115783 | + |
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FusionProtFeatures for SEMA3C_CD36 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEMA3C | CD36 |