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Fusion gene ID: 33107

FusionGeneSummary for SECISBP2_NEDD4L

Fusion gene summary

Fusion gene information	Fusion gene name: SECISBP2_NEDD4L
	Fusion gene ID: 33107
		Hgene	Tgene
	Gene symbol	SECISBP2	NEDD4L
	Gene ID	79048	23327
	Gene name	SECIS binding protein 2	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
	Synonyms	SBP2	NEDD4-2\|NEDD4.2\|PVNH7\|RSP5\|hNEDD4-2
	Cytomap	9q22.2	18q21.31
	Type of gene	protein-coding	protein-coding
	Description	selenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2	E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lubiquitin-protein ligase Rsp5
	Modification date	20180523	20180523
	UniProtAcc	Q96T21	Q96PU5
	Ensembl transtripts involved in fusion gene	ENST00000375807, ENST00000339901, ENST00000534113, ENST00000470305,	ENST00000356462, ENST00000400345, ENST00000589054, ENST00000256832, ENST00000382850, ENST00000256830, ENST00000588516, ENST00000456986, ENST00000435432, ENST00000357895, ENST00000586263, ENST00000456173, ENST00000431212,
Fusion gene scores	* DoF score	5 X 6 X 2=60	13 X 14 X 6=1092
	# samples	6	16
	** MAII score	log2(6/60*10)=0	log2(16/1092*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SECISBP2 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NEDD4L	GO:0003254	regulation of membrane depolarization	15217910
Tgene	NEDD4L	GO:0006511	ubiquitin-dependent protein catabolic process	21463633
Tgene	NEDD4L	GO:0010038	response to metal ion	11244092
Tgene	NEDD4L	GO:0016567	protein ubiquitination	15217910\|25631046
Tgene	NEDD4L	GO:0034765	regulation of ion transmembrane transport	17289006
Tgene	NEDD4L	GO:0042391	regulation of membrane potential	17289006
Tgene	NEDD4L	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21463633
Tgene	NEDD4L	GO:0060306	regulation of membrane repolarization	21463633
Tgene	NEDD4L	GO:0070936	protein K48-linked ubiquitination	21463633
Tgene	NEDD4L	GO:1901016	regulation of potassium ion transmembrane transporter activity	17289006
Tgene	NEDD4L	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	21463633
Tgene	NEDD4L	GO:1901380	negative regulation of potassium ion transmembrane transport	21463633
Tgene	NEDD4L	GO:1902306	negative regulation of sodium ion transmembrane transport	15217910
Tgene	NEDD4L	GO:1903861	positive regulation of dendrite extension	23999003
Tgene	NEDD4L	GO:2000009	negative regulation of protein localization to cell surface	21463633
Tgene	NEDD4L	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	15217910

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUAD	TCGA-86-8075-01A	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000375807	ENST00000356462	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000375807	ENST00000400345	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000375807	ENST00000589054	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000375807	ENST00000256832	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
In-frame	ENST00000375807	ENST00000382850	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000375807	ENST00000256830	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000375807	ENST00000588516	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000375807	ENST00000456986	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000375807	ENST00000435432	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000375807	ENST00000357895	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000375807	ENST00000586263	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000375807	ENST00000456173	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000375807	ENST00000431212	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
In-frame	ENST00000339901	ENST00000356462	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000339901	ENST00000400345	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000339901	ENST00000589054	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000339901	ENST00000256832	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
In-frame	ENST00000339901	ENST00000382850	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000339901	ENST00000256830	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000339901	ENST00000588516	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000339901	ENST00000456986	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000339901	ENST00000435432	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000339901	ENST00000357895	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000339901	ENST00000586263	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000339901	ENST00000456173	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000339901	ENST00000431212	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
In-frame	ENST00000534113	ENST00000356462	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000534113	ENST00000400345	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000534113	ENST00000589054	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000534113	ENST00000256832	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
In-frame	ENST00000534113	ENST00000382850	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
Frame-shift	ENST00000534113	ENST00000256830	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000534113	ENST00000588516	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000534113	ENST00000456986	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000534113	ENST00000435432	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000534113	ENST00000357895	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000534113	ENST00000586263	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000534113	ENST00000456173	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
5CDS-intron	ENST00000534113	ENST00000431212	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-3CDS	ENST00000470305	ENST00000356462	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-3CDS	ENST00000470305	ENST00000400345	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-3CDS	ENST00000470305	ENST00000589054	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-3CDS	ENST00000470305	ENST00000256832	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-3CDS	ENST00000470305	ENST00000382850	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-3CDS	ENST00000470305	ENST00000256830	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-intron	ENST00000470305	ENST00000588516	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-intron	ENST00000470305	ENST00000456986	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-intron	ENST00000470305	ENST00000435432	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-intron	ENST00000470305	ENST00000357895	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-intron	ENST00000470305	ENST00000586263	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-intron	ENST00000470305	ENST00000456173	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+
intron-intron	ENST00000470305	ENST00000431212	SECISBP2	chr9	91956394	+	NEDD4L	chr18	56063399	+

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FusionProtFeatures for SECISBP2_NEDD4L

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SECISBP2 Q96T21	NEDD4L Q96PU5

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Fusion gene ID: 33107

FusionGeneSummary for SECISBP2_NEDD4L

FusionProtFeatures for SECISBP2_NEDD4L