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Fusion gene ID: 33087 |
FusionGeneSummary for SEC61B_SIT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEC61B_SIT1 | Fusion gene ID: 33087 | Hgene | Tgene | Gene symbol | SEC61B | SIT1 | Gene ID | 10952 | 54716 |
| Gene name | Sec61 translocon beta subunit | solute carrier family 6 member 20 | |
| Synonyms | - | SIT1|XT3|Xtrp3 | |
| Cytomap | 9q22.33 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein transport protein Sec61 subunit betaSec61 beta subunitSec61 complex, beta subunitprotein translocation complex betaprotein transport protein SEC61 beta subunit | sodium- and chloride-dependent transporter XTRP3X transporter protein 3neurotransmitter transporter RB21Aorphan transporter XT3sodium/imino-acid transporter 1solute carrier family 6 (neurotransmitter transporter), member 20solute carrier family 6 (p | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P60468 | Q9Y3P8 | |
| Ensembl transtripts involved in fusion gene | ENST00000498603, ENST00000223641, ENST00000481573, | ENST00000259608, ENST00000474403, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/8*10)=2.32192809488736 | |
| Context | PubMed: SEC61B [Title/Abstract] AND SIT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SEC61B | GO:0030433 | ubiquitin-dependent ERAD pathway | 8945469 |
| Tgene | SIT1 | GO:0006865 | amino acid transport | 15632147 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A1J9-01A | SEC61B | chr9 | 101984925 | + | SIT1 | chr9 | 35650944 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000498603 | ENST00000259608 | SEC61B | chr9 | 101984925 | + | SIT1 | chr9 | 35650944 | - |
| 5UTR-intron | ENST00000498603 | ENST00000474403 | SEC61B | chr9 | 101984925 | + | SIT1 | chr9 | 35650944 | - |
| 5CDS-intron | ENST00000223641 | ENST00000259608 | SEC61B | chr9 | 101984925 | + | SIT1 | chr9 | 35650944 | - |
| 5CDS-intron | ENST00000223641 | ENST00000474403 | SEC61B | chr9 | 101984925 | + | SIT1 | chr9 | 35650944 | - |
| 3UTR-intron | ENST00000481573 | ENST00000259608 | SEC61B | chr9 | 101984925 | + | SIT1 | chr9 | 35650944 | - |
| 3UTR-intron | ENST00000481573 | ENST00000474403 | SEC61B | chr9 | 101984925 | + | SIT1 | chr9 | 35650944 | - |
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FusionProtFeatures for SEC61B_SIT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEC61B | SIT1 |