|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 33080 |
FusionGeneSummary for SEC61A1_INPP4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEC61A1_INPP4B | Fusion gene ID: 33080 | Hgene | Tgene | Gene symbol | SEC61A1 | INPP4B | Gene ID | 29927 | 8821 |
| Gene name | Sec61 translocon alpha 1 subunit | inositol polyphosphate-4-phosphatase type II B | |
| Synonyms | HNFJ4|HSEC61|SEC61|SEC61A | - | |
| Cytomap | 3q21.3 | 4q31.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein transport protein Sec61 subunit alpha isoform 1Sec61 alpha 1 subunitSec61 alpha-1protein transport protein SEC61 alpha subunitprotein transport protein Sec61 subunit alphasec61 homolog | type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P61619 | O15327 | |
| Ensembl transtripts involved in fusion gene | ENST00000464451, ENST00000243253, ENST00000424880, ENST00000483956, | ENST00000513000, ENST00000509777, ENST00000262992, ENST00000308502, ENST00000508116, ENST00000507861, ENST00000506217, ENST00000508084, | |
| Fusion gene scores | * DoF score | 8 X 9 X 6=432 | 9 X 7 X 6=378 |
| # samples | 10 | 9 | |
| ** MAII score | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SEC61A1 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A3UA-01A | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000464451 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000464451 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000464451 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000464451 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000464451 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000464451 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000464451 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000464451 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| Frame-shift | ENST00000243253 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000243253 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000243253 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000243253 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000243253 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000243253 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000243253 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000243253 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| Frame-shift | ENST00000424880 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000424880 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000424880 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000424880 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000424880 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000424880 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000424880 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 5CDS-intron | ENST00000424880 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-3CDS | ENST00000483956 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-intron | ENST00000483956 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-intron | ENST00000483956 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-intron | ENST00000483956 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-intron | ENST00000483956 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-intron | ENST00000483956 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-intron | ENST00000483956 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
| 3UTR-intron | ENST00000483956 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
Top |
FusionProtFeatures for SEC61A1_INPP4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEC61A1 | INPP4B |