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Fusion gene ID: 32971 |
FusionGeneSummary for SDHAF2_RIN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SDHAF2_RIN1 | Fusion gene ID: 32971 | Hgene | Tgene | Gene symbol | SDHAF2 | RIN1 | Gene ID | 54949 | 9610 |
| Gene name | succinate dehydrogenase complex assembly factor 2 | Ras and Rab interactor 1 | |
| Synonyms | C11orf79|PGL2|SDH5 | - | |
| Cytomap | 11q12.2 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | succinate dehydrogenase assembly factor 2, mitochondrialSDH assembly factor 2hSDH5succinate dehydrogenase subunit 5, mitochondrial | ras and Rab interactor 1ras inhibitor 1ras inhibitor JC99ras inhibitor RIN1ras interaction/interference protein 1 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q9NX18 | Q13671 | |
| Ensembl transtripts involved in fusion gene | ENST00000301761, ENST00000542074, ENST00000537782, ENST00000543265, ENST00000534878, | ENST00000311320, ENST00000424433, ENST00000530056, ENST00000524804, | |
| Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SDHAF2 [Title/Abstract] AND RIN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A06N-01A | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| TCGA | LD | BRCA | TCGA-A8-A06N-01A | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000301761 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000301761 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000301761 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000301761 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000542074 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000542074 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000542074 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-intron | ENST00000542074 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000537782 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000537782 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| In-frame | ENST00000537782 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000537782 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000543265 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000543265 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-3CDS | ENST00000543265 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| intron-intron | ENST00000543265 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000311320 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000424433 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000530056 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000534878 | ENST00000524804 | SDHAF2 | chr11 | 61205585 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000301761 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000301761 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000301761 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000301761 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000542074 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000542074 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000542074 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000542074 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000537782 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000537782 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000537782 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000537782 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000543265 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000543265 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000543265 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000543265 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000311320 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000424433 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| Frame-shift | ENST00000534878 | ENST00000530056 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
| 5CDS-intron | ENST00000534878 | ENST00000524804 | SDHAF2 | chr11 | 61197654 | + | RIN1 | chr11 | 66101129 | - |
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FusionProtFeatures for SDHAF2_RIN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SDHAF2 | RIN1 |