|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 32895 |
FusionGeneSummary for SCRN2_CBX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCRN2_CBX1 | Fusion gene ID: 32895 | Hgene | Tgene | Gene symbol | SCRN2 | CBX1 | Gene ID | 90507 | 10951 |
| Gene name | secernin 2 | chromobox 1 | |
| Synonyms | Ses2 | CBX|HP1-BETA|HP1Hs-beta|HP1Hsbeta|M31|MOD1|p25beta | |
| Cytomap | 17q21.32 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | secernin-2 | chromobox protein homolog 1HP1 beta homologchromobox homolog 1 (HP1 beta homolog Drosophila )heterochromatin protein 1 homolog betaheterochromatin protein 1-betaheterochromatin protein p25 betamodifier 1 protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q96FV2 | P83916 | |
| Ensembl transtripts involved in fusion gene | ENST00000407215, ENST00000290216, ENST00000584123, | ENST00000393408, ENST00000225603, ENST00000495350, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 4 X 2 X 4=32 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SCRN2 [Title/Abstract] AND CBX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-EY-A4KR-01A | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000407215 | ENST00000393408 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| Frame-shift | ENST00000407215 | ENST00000225603 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| Frame-shift | ENST00000407215 | ENST00000495350 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| Frame-shift | ENST00000290216 | ENST00000393408 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| Frame-shift | ENST00000290216 | ENST00000225603 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| Frame-shift | ENST00000290216 | ENST00000495350 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| In-frame | ENST00000584123 | ENST00000393408 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| In-frame | ENST00000584123 | ENST00000225603 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
| In-frame | ENST00000584123 | ENST00000495350 | SCRN2 | chr17 | 45918036 | - | CBX1 | chr17 | 46152462 | - |
Top |
FusionProtFeatures for SCRN2_CBX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCRN2 | CBX1 |