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Fusion gene ID: 32884

FusionGeneSummary for SCP2_NCAM1

Fusion gene summary

Fusion gene information	Fusion gene name: SCP2_NCAM1
	Fusion gene ID: 32884
		Hgene	Tgene
	Gene symbol	SCP2	NCAM1
	Gene ID	10388	4684
	Gene name	synaptonemal complex protein 2	neural cell adhesion molecule 1
	Synonyms	SCP-2\|SCP2	CD56\|MSK39\|NCAM
	Cytomap	20q13.33	11q23.2
	Type of gene	protein-coding	protein-coding
	Description	synaptonemal complex protein 2synaptonemal complex lateral element protein	neural cell adhesion molecule 1antigen recognized by monoclonal antibody 5.1H11neural cell adhesion molecule, NCAM
	Modification date	20180519	20180523
	UniProtAcc	P22307	P13591
	Ensembl transtripts involved in fusion gene	ENST00000371514, ENST00000528311, ENST00000371509, ENST00000407246, ENST00000371513, ENST00000473584, ENST00000430330, ENST00000408941, ENST00000435345, ENST00000488965,	ENST00000533760, ENST00000397957, ENST00000316851, ENST00000401611,
Fusion gene scores	* DoF score	6 X 5 X 4=120	8 X 9 X 4=288
	# samples	6	10
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SCP2 [Title/Abstract] AND NCAM1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-V1-A9ZG-01A	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
TCGA	LD	PRAD	TCGA-V1-A9ZG-01A	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000371514	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371514	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371514	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000371514	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-3CDS	ENST00000528311	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-3UTR	ENST00000528311	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-3UTR	ENST00000528311	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-intron	ENST00000528311	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000371509	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371509	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371509	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000371509	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000407246	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000407246	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000407246	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000407246	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000371513	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371513	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371513	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000371513	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000473584	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000473584	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000473584	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000473584	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000430330	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000430330	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000430330	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000430330	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000408941	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000408941	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000408941	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000408941	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000435345	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000435345	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000435345	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000435345	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000488965	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000488965	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000488965	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000488965	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000371514	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371514	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371514	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000371514	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-3CDS	ENST00000528311	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-3UTR	ENST00000528311	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-3UTR	ENST00000528311	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-intron	ENST00000528311	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
Frame-shift	ENST00000371509	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371509	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371509	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000371509	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
Frame-shift	ENST00000407246	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000407246	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000407246	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000407246	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
Frame-shift	ENST00000371513	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371513	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371513	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000371513	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000473584	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000473584	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000473584	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000473584	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000430330	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000430330	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000430330	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000430330	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000408941	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000408941	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000408941	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000408941	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000435345	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000435345	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000435345	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000435345	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000488965	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000488965	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000488965	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000488965	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+

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FusionProtFeatures for SCP2_NCAM1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SCP2 P22307	NCAM1 P13591

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Fusion gene ID: 32884

FusionGeneSummary for SCP2_NCAM1

FusionProtFeatures for SCP2_NCAM1