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Fusion gene ID: 32838 |
FusionGeneSummary for SCLT1_DNAJB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCLT1_DNAJB1 | Fusion gene ID: 32838 | Hgene | Tgene | Gene symbol | SCLT1 | DNAJB1 | Gene ID | 132320 | 3337 |
| Gene name | sodium channel and clathrin linker 1 | DnaJ heat shock protein family (Hsp40) member B1 | |
| Synonyms | CAP-1A|CAP1A | HSPF1|Hdj1|Hsp40|RSPH16B|Sis1 | |
| Cytomap | 4q28.2 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium channel and clathrin linker 1sodium channel-associated protein 1 | dnaJ homolog subfamily B member 1DnaJ (Hsp40) homolog, subfamily B, member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog B | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96NL6 | P25685 | |
| Ensembl transtripts involved in fusion gene | ENST00000281142, ENST00000434680, ENST00000439369, ENST00000503215, ENST00000502495, ENST00000506368, ENST00000511426, ENST00000503401, | ENST00000254322, ENST00000396969, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SCLT1 [Title/Abstract] AND DNAJB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DNAJB1 | GO:0032781 | positive regulation of ATPase activity | 23921388 |
| Tgene | DNAJB1 | GO:0051085 | chaperone cofactor-dependent protein refolding | 18620420 |
| Tgene | DNAJB1 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
| Tgene | DNAJB1 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress | 9499401 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW380464 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000281142 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000281142 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000434680 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000434680 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000439369 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000439369 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503215 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503215 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000502495 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000502495 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000506368 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000506368 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000511426 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000511426 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503401 | ENST00000254322 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
| intron-3CDS | ENST00000503401 | ENST00000396969 | SCLT1 | chr4 | 129805431 | - | DNAJB1 | chr19 | 14627463 | - |
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FusionProtFeatures for SCLT1_DNAJB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCLT1 | DNAJB1 |