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Fusion gene ID: 32822 |
FusionGeneSummary for SCFD2_NARS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCFD2_NARS2 | Fusion gene ID: 32822 | Hgene | Tgene | Gene symbol | SCFD2 | NARS2 | Gene ID | 152579 | 79731 |
| Gene name | sec1 family domain containing 2 | asparaginyl-tRNA synthetase 2, mitochondrial | |
| Synonyms | STXBP1L1 | DFNB94|SLM5|asnRS | |
| Cytomap | 4q12 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sec1 family domain-containing protein 2syntaxin binding protein 1-like 1 | probable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrial | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8WU76 | Q96I59 | |
| Ensembl transtripts involved in fusion gene | ENST00000401642, ENST00000388940, | ENST00000281038, ENST00000528850, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 20 X 8 X 9=1440 |
| # samples | 8 | 20 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1440*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SCFD2 [Title/Abstract] AND NARS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-8074-01A | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000401642 | ENST00000281038 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| In-frame | ENST00000401642 | ENST00000528850 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| In-frame | ENST00000388940 | ENST00000281038 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
| In-frame | ENST00000388940 | ENST00000528850 | SCFD2 | chr4 | 54218765 | - | NARS2 | chr11 | 78180359 | - |
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FusionProtFeatures for SCFD2_NARS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCFD2 | NARS2 |