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Fusion gene ID: 32818

FusionGeneSummary for SCFD2_FIP1L1

Fusion gene summary

Fusion gene information	Fusion gene name: SCFD2_FIP1L1
	Fusion gene ID: 32818
		Hgene	Tgene
	Gene symbol	SCFD2	FIP1L1
	Gene ID	152579	81608
	Gene name	sec1 family domain containing 2	factor interacting with PAPOLA and CPSF1
	Synonyms	STXBP1L1	FIP1\|Rhe\|hFip1
	Cytomap	4q12	4q12
	Type of gene	protein-coding	protein-coding
	Description	sec1 family domain-containing protein 2syntaxin binding protein 1-like 1	pre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
	Modification date	20180519	20180523
	UniProtAcc	Q8WU76	Q6UN15
	Ensembl transtripts involved in fusion gene	ENST00000401642, ENST00000388940,	ENST00000507166, ENST00000358575, ENST00000337488, ENST00000507922, ENST00000306932, ENST00000510668,
Fusion gene scores	* DoF score	7 X 6 X 4=168	9 X 10 X 5=450
	# samples	8	13
	** MAII score	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SCFD2 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LGG	TCGA-S9-A6WQ-01A	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000401642	ENST00000507166	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000401642	ENST00000358575	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000401642	ENST00000337488	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000401642	ENST00000507922	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000401642	ENST00000306932	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
5CDS-intron	ENST00000401642	ENST00000510668	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000388940	ENST00000507166	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000388940	ENST00000358575	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000388940	ENST00000337488	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000388940	ENST00000507922	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
In-frame	ENST00000388940	ENST00000306932	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+
5CDS-intron	ENST00000388940	ENST00000510668	SCFD2	chr4	54218765	-	FIP1L1	chr4	54292039	+

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FusionProtFeatures for SCFD2_FIP1L1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SCFD2 Q8WU76	FIP1L1 Q6UN15

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Fusion gene ID: 32818

FusionGeneSummary for SCFD2_FIP1L1

FusionProtFeatures for SCFD2_FIP1L1