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Fusion gene ID: 32813 |
FusionGeneSummary for SCD_SEC61A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCD_SEC61A2 | Fusion gene ID: 32813 | Hgene | Tgene | Gene symbol | SCD | SEC61A2 | Gene ID | 6319 | 55176 |
| Gene name | stearoyl-CoA desaturase | Sec61 translocon alpha 2 subunit | |
| Synonyms | FADS5|MSTP008|SCD1|SCDOS|hSCD1 | - | |
| Cytomap | 10q24.31 | 10p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acyl-CoA desaturasedelta(9)-desaturasefatty acid desaturasepredicted protein of HQ0998stearoyl-CoA desaturase (delta-9-desaturase)stearoyl-CoA desaturase opposite strand | protein transport protein Sec61 subunit alpha isoform 2Sec61 alpha 2 subunitSec61 alpha form 2protein transport protein Sec61 subunit alphasec61 alpha-2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00767 | Q9H9S3 | |
| Ensembl transtripts involved in fusion gene | ENST00000370355, | ENST00000379051, ENST00000379033, ENST00000298428, ENST00000495368, ENST00000304267, ENST00000379020, ENST00000379017, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 4 X 2=24 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SCD [Title/Abstract] AND SEC61A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SCD | GO:0006636 | unsaturated fatty acid biosynthetic process | 15907797|18765284 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-TM-A84J-01A | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000370355 | ENST00000379051 | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
| In-frame | ENST00000370355 | ENST00000379033 | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
| In-frame | ENST00000370355 | ENST00000298428 | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
| 5CDS-3UTR | ENST00000370355 | ENST00000495368 | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
| 5CDS-3UTR | ENST00000370355 | ENST00000304267 | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
| 5CDS-3UTR | ENST00000370355 | ENST00000379020 | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
| 5CDS-3UTR | ENST00000370355 | ENST00000379017 | SCD | chr10 | 102116521 | + | SEC61A2 | chr10 | 12191594 | + |
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FusionProtFeatures for SCD_SEC61A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCD | SEC61A2 |