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Fusion gene ID: 32790 |
FusionGeneSummary for SCARB2_CYP19A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SCARB2_CYP19A1 | Fusion gene ID: 32790 | Hgene | Tgene | Gene symbol | SCARB2 | CYP19A1 | Gene ID | 950 | 1588 |
| Gene name | scavenger receptor class B member 2 | cytochrome P450 family 19 subfamily A member 1 | |
| Synonyms | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | ARO|ARO1|CPV1|CYAR|CYP19|CYPXIX|P-450AROM | |
| Cytomap | 4q21.1 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | aromatasecytochrome P-450AROMcytochrome P450 19A1cytochrome P450, family 19, subfamily A, polypeptide 1cytochrome P450, subfamily XIX (aromatization of androgens)estrogen synthaseestrogen synthetaseflavoprotein-linked monooxygenasemicrosomal monoo | |
| Modification date | 20180519 | 20180520 | |
| UniProtAcc | Q14108 | P11511 | |
| Ensembl transtripts involved in fusion gene | ENST00000264896, ENST00000452464, | ENST00000396402, ENST00000260433, ENST00000396404, ENST00000559878, ENST00000405913, ENST00000557858, ENST00000492852, | |
| Fusion gene scores | * DoF score | 11 X 9 X 5=495 | 9 X 9 X 3=243 |
| # samples | 11 | 11 | |
| ** MAII score | log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/243*10)=-1.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SCARB2 [Title/Abstract] AND CYP19A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CYP19A1 | GO:0006710 | androgen catabolic process | 26482249 |
| Tgene | CYP19A1 | GO:2000866 | positive regulation of estradiol secretion | 26482249 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF989796 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000264896 | ENST00000396402 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000264896 | ENST00000260433 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000264896 | ENST00000396404 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000264896 | ENST00000559878 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000264896 | ENST00000405913 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000264896 | ENST00000557858 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-intron | ENST00000264896 | ENST00000492852 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000452464 | ENST00000396402 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000452464 | ENST00000260433 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000452464 | ENST00000396404 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000452464 | ENST00000559878 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000452464 | ENST00000405913 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-3CDS | ENST00000452464 | ENST00000557858 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
| intron-intron | ENST00000452464 | ENST00000492852 | SCARB2 | chr4 | 77082719 | - | CYP19A1 | chr15 | 51535047 | - |
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FusionProtFeatures for SCARB2_CYP19A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SCARB2 | CYP19A1 |