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Fusion gene ID: 32705 |
FusionGeneSummary for SBF2_PGAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SBF2_PGAP2 | Fusion gene ID: 32705 | Hgene | Tgene | Gene symbol | SBF2 | PGAP2 | Gene ID | 81846 | 27315 |
| Gene name | SET binding factor 2 | post-GPI attachment to proteins 2 | |
| Synonyms | CMT4B2|DENND7B|MTMR13 | CWH43-N|FRAG1|HPMRS3|MRT17|MRT21 | |
| Cytomap | 11p15.4 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myotubularin-related protein 13DENN/MADD domain containing 7B | post-GPI attachment to proteins factor 2FGF receptor activating protein 1cell wall biogenesis 43 N-terminal homologmental retardation, non-syndromic, autosomal recessive, 21 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q86WG5 | Q9UHJ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000256190, ENST00000527019, | ENST00000396986, ENST00000300730, ENST00000396993, ENST00000396991, ENST00000532017, ENST00000465307, ENST00000493547, ENST00000278243, ENST00000463452, ENST00000479072, ENST00000496834, | |
| Fusion gene scores | * DoF score | 16 X 9 X 8=1152 | 3 X 3 X 3=27 |
| # samples | 16 | 3 | |
| ** MAII score | log2(16/1152*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SBF2 [Title/Abstract] AND PGAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A08G-01A | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000256190 | ENST00000396986 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| In-frame | ENST00000256190 | ENST00000300730 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| Frame-shift | ENST00000256190 | ENST00000396993 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| In-frame | ENST00000256190 | ENST00000396991 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| 5CDS-3UTR | ENST00000256190 | ENST00000532017 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| 5CDS-3UTR | ENST00000256190 | ENST00000465307 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| 5CDS-3UTR | ENST00000256190 | ENST00000493547 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| 5CDS-3UTR | ENST00000256190 | ENST00000278243 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| 5CDS-3UTR | ENST00000256190 | ENST00000463452 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| 5CDS-5UTR | ENST00000256190 | ENST00000479072 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| 5CDS-5UTR | ENST00000256190 | ENST00000496834 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3CDS | ENST00000527019 | ENST00000396986 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3CDS | ENST00000527019 | ENST00000300730 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3CDS | ENST00000527019 | ENST00000396993 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3CDS | ENST00000527019 | ENST00000396991 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3UTR | ENST00000527019 | ENST00000532017 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3UTR | ENST00000527019 | ENST00000465307 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3UTR | ENST00000527019 | ENST00000493547 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3UTR | ENST00000527019 | ENST00000278243 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-3UTR | ENST00000527019 | ENST00000463452 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-5UTR | ENST00000527019 | ENST00000479072 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
| intron-5UTR | ENST00000527019 | ENST00000496834 | SBF2 | chr11 | 10011044 | - | PGAP2 | chr11 | 3845113 | + |
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FusionProtFeatures for SBF2_PGAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SBF2 | PGAP2 |