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Fusion gene ID: 32700 |
FusionGeneSummary for SBF2_MDM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SBF2_MDM2 | Fusion gene ID: 32700 | Hgene | Tgene | Gene symbol | SBF2 | MDM2 | Gene ID | 81846 | 4193 |
| Gene name | SET binding factor 2 | MDM2 proto-oncogene | |
| Synonyms | CMT4B2|DENND7B|MTMR13 | ACTFS|HDMX|hdm2 | |
| Cytomap | 11p15.4 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myotubularin-related protein 13DENN/MADD domain containing 7B | E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q86WG5 | Q00987 | |
| Ensembl transtripts involved in fusion gene | ENST00000256190, ENST00000527019, | ENST00000462284, ENST00000356290, ENST00000540827, ENST00000258149, ENST00000428863, ENST00000393412, ENST00000258148, ENST00000544561, ENST00000393410, ENST00000393413, ENST00000517852, ENST00000545204, ENST00000350057, ENST00000360430, ENST00000299252, ENST00000348801, ENST00000478070, ENST00000544125, | |
| Fusion gene scores | * DoF score | 16 X 9 X 8=1152 | 10 X 7 X 6=420 |
| # samples | 16 | 9 | |
| ** MAII score | log2(16/1152*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/420*10)=-2.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SBF2 [Title/Abstract] AND MDM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MDM2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9271120|17310983 |
| Tgene | MDM2 | GO:0006511 | ubiquitin-dependent protein catabolic process | 11278372|15314173|16173922|17310983 |
| Tgene | MDM2 | GO:0016567 | protein ubiquitination | 9450543|15878855|19656744|20153724 |
| Tgene | MDM2 | GO:0031648 | protein destabilization | 9529249|10360174|15314173 |
| Tgene | MDM2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 11278372 |
| Tgene | MDM2 | GO:0034504 | protein localization to nucleus | 10360174 |
| Tgene | MDM2 | GO:0042176 | regulation of protein catabolic process | 9153395 |
| Tgene | MDM2 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 9529249|10360174 |
| Tgene | MDM2 | GO:0045184 | establishment of protein localization | 10360174 |
| Tgene | MDM2 | GO:0045892 | negative regulation of transcription, DNA-templated | 9271120 |
| Tgene | MDM2 | GO:0065003 | protein-containing complex assembly | 10608892|12915590 |
| Tgene | MDM2 | GO:0071157 | negative regulation of cell cycle arrest | 9529249 |
| Tgene | MDM2 | GO:0071480 | cellular response to gamma radiation | 16213212 |
| Tgene | MDM2 | GO:0072717 | cellular response to actinomycin D | 15314173 |
| Tgene | MDM2 | GO:1901797 | negative regulation of signal transduction by p53 class mediator | 16173922 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A06U-01A | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000256190 | ENST00000462284 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000356290 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000540827 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000258149 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000428863 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000393412 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000258148 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000544561 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000393410 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000393413 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000517852 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000545204 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000350057 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000360430 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000299252 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000348801 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000478070 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| 5CDS-intron | ENST00000256190 | ENST00000544125 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-3CDS | ENST00000527019 | ENST00000462284 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000356290 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000540827 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000258149 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000428863 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000393412 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000258148 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000544561 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000393410 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000393413 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000517852 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000545204 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000350057 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000360430 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000299252 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000348801 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000478070 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
| intron-intron | ENST00000527019 | ENST00000544125 | SBF2 | chr11 | 9983504 | - | MDM2 | chr12 | 69210592 | + |
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FusionProtFeatures for SBF2_MDM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SBF2 | MDM2 |