	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 32662

FusionGeneSummary for SASH1_ARID1B

Fusion gene summary

Fusion gene information	Fusion gene name: SASH1_ARID1B
	Fusion gene ID: 32662
		Hgene	Tgene
	Gene symbol	SASH1	ARID1B
	Gene ID	23328	57492
	Gene name	SAM and SH3 domain containing 1	AT-rich interaction domain 1B
	Synonyms	SH3D6A\|dJ323M4.1	6A3-5\|BAF250B\|BRIGHT\|CSS1\|DAN15\|ELD/OSA1\|MRD12\|OSA2\|P250R
	Cytomap	6q24.3-q25.1	6q25.3
	Type of gene	protein-coding	protein-coding
	Description	SAM and SH3 domain-containing protein 1proline-glutamate repeat-containing protein	AT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein
	Modification date	20180523	20180529
	UniProtAcc	O94885	Q8NFD5
	Ensembl transtripts involved in fusion gene	ENST00000367469, ENST00000367467, ENST00000470750,	ENST00000350026, ENST00000346085, ENST00000367148, ENST00000275248, ENST00000478761,
Fusion gene scores	* DoF score	9 X 6 X 6=324	5 X 6 X 3=90
	# samples	8	6
	** MAII score	log2(8/324*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SASH1 [Title/Abstract] AND ARID1B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SASH1	GO:0000209	protein polyubiquitination	23776175
Hgene	SASH1	GO:0010595	positive regulation of endothelial cell migration	23776175
Hgene	SASH1	GO:1900044	regulation of protein K63-linked ubiquitination	23776175
Hgene	SASH1	GO:1902498	regulation of protein autoubiquitination	23776175

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-E9-A1NF-01A	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000367469	ENST00000350026	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
In-frame	ENST00000367469	ENST00000346085	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
In-frame	ENST00000367469	ENST00000367148	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
In-frame	ENST00000367469	ENST00000275248	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
5CDS-intron	ENST00000367469	ENST00000478761	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
In-frame	ENST00000367467	ENST00000350026	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
In-frame	ENST00000367467	ENST00000346085	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
In-frame	ENST00000367467	ENST00000367148	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
In-frame	ENST00000367467	ENST00000275248	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
5CDS-intron	ENST00000367467	ENST00000478761	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
intron-3CDS	ENST00000470750	ENST00000350026	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
intron-3CDS	ENST00000470750	ENST00000346085	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
intron-3CDS	ENST00000470750	ENST00000367148	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
intron-3CDS	ENST00000470750	ENST00000275248	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+
intron-intron	ENST00000470750	ENST00000478761	SASH1	chr6	148711398	+	ARID1B	chr6	157256600	+

Top

FusionProtFeatures for SASH1_ARID1B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SASH1 O94885	ARID1B Q8NFD5

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 32662

FusionGeneSummary for SASH1_ARID1B

FusionProtFeatures for SASH1_ARID1B