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Fusion gene ID: 32646

FusionGeneSummary for SARNP_VAMP8

Fusion gene summary

Fusion gene information	Fusion gene name: SARNP_VAMP8
	Fusion gene ID: 32646
		Hgene	Tgene
	Gene symbol	SARNP	VAMP8
	Gene ID	84324	8673
	Gene name	SAP domain containing ribonucleoprotein	vesicle associated membrane protein 8
	Synonyms	CIP29\|HCC1\|HSPC316\|THO1	EDB\|VAMP-8
	Cytomap	12q13.2	2p11.2
	Type of gene	protein-coding	protein-coding
	Description	SAP domain-containing ribonucleoproteincytokine induced protein 29 kDacytokine-induced protein of 29 kDahepatocellular carcinoma 1nuclear protein Hcc-1proliferation associated cytokine-inducible protein CIP29	vesicle-associated membrane protein 8vesicle-associated membrane protein 8 (endobrevin)
	Modification date	20180522	20180522
	UniProtAcc	P82979	Q9BV40
	Ensembl transtripts involved in fusion gene	ENST00000444631, ENST00000336133, ENST00000552080,	ENST00000432071, ENST00000263864, ENST00000409760,
Fusion gene scores	* DoF score	10 X 5 X 8=400	3 X 2 X 3=18
	# samples	11	3
	** MAII score	log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SARNP [Title/Abstract] AND VAMP8 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SARNP	GO:0006406	mRNA export from nucleus	20844015
Tgene	VAMP8	GO:0016240	autophagosome membrane docking	25686604
Tgene	VAMP8	GO:1903076	regulation of protein localization to plasma membrane	18570918
Tgene	VAMP8	GO:1903531	negative regulation of secretion by cell	12130530

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUSC	TCGA-NC-A5HQ-01A	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000444631	ENST00000432071	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000444631	ENST00000263864	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000444631	ENST00000409760	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000336133	ENST00000432071	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000336133	ENST00000263864	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000336133	ENST00000409760	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000552080	ENST00000432071	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000552080	ENST00000263864	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+
5CDS-5UTR	ENST00000552080	ENST00000409760	SARNP	chr12	56182859	-	VAMP8	chr2	85806132	+

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FusionProtFeatures for SARNP_VAMP8

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SARNP P82979	VAMP8 Q9BV40

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Fusion gene ID: 32646

FusionGeneSummary for SARNP_VAMP8

FusionProtFeatures for SARNP_VAMP8