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Fusion gene ID: 32633 |
FusionGeneSummary for SAR1A_NPFFR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SAR1A_NPFFR1 | Fusion gene ID: 32633 | Hgene | Tgene | Gene symbol | SAR1A | NPFFR1 | Gene ID | 56681 | 64106 |
| Gene name | secretion associated Ras related GTPase 1A | neuropeptide FF receptor 1 | |
| Synonyms | SAR1|SARA1|Sara|masra2 | GPR147|NPFF1|NPFF1R1|OT7T022 | |
| Cytomap | 10q22.1 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GTP-binding protein SAR1aCOPII-associated small GTPaseSAR1 gene homolog ASAR1 homolog ASAR1a gene homolog 1 | neuropeptide FF receptor 1G-protein coupled receptor 147RFamide-related peptide receptor OT7T022neuropeptide FF 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NR31 | Q9GZQ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000373242, ENST00000373238, ENST00000373241, ENST00000431664, ENST00000458634, ENST00000373236, ENST00000477464, | ENST00000277942, | |
| Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SAR1A [Title/Abstract] AND NPFFR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SAR1A | GO:0090110 | cargo loading into COPII-coated vesicle | 17499046|18843296 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-38-4630-01A | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000373242 | ENST00000277942 | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
| intron-3CDS | ENST00000373238 | ENST00000277942 | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
| 5UTR-3CDS | ENST00000373241 | ENST00000277942 | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
| intron-3CDS | ENST00000431664 | ENST00000277942 | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
| 5UTR-3CDS | ENST00000458634 | ENST00000277942 | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
| intron-3CDS | ENST00000373236 | ENST00000277942 | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
| intron-3CDS | ENST00000477464 | ENST00000277942 | SAR1A | chr10 | 71930169 | - | NPFFR1 | chr10 | 72026147 | - |
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FusionProtFeatures for SAR1A_NPFFR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SAR1A | NPFFR1 |