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Fusion gene ID: 32525 |
FusionGeneSummary for SAA1_CRIP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SAA1_CRIP2 | Fusion gene ID: 32525 | Hgene | Tgene | Gene symbol | SAA1 | CRIP2 | Gene ID | 6288 | 1397 |
| Gene name | serum amyloid A1 | cysteine rich protein 2 | |
| Synonyms | PIG4|SAA|SAA2|TP53I4 | CRIP|CRP2|ESP1 | |
| Cytomap | 11p15.1 | 14q32.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serum amyloid A-1 proteinserum amyloid A proteintumor protein p53 inducible protein 4 | cysteine-rich protein 2Cysteine-rich intestinal proteinLIM domain protein ESP1/CRP2 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P0DJI8 | P52943 | |
| Ensembl transtripts involved in fusion gene | ENST00000356524, ENST00000532858, ENST00000405158, | ENST00000483017, ENST00000329146, ENST00000548989, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 4 X 3 X 2=24 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SAA1 [Title/Abstract] AND CRIP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SAA1 | GO:0000187 | activation of MAPK activity | 22532826 |
| Hgene | SAA1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 9892621 |
| Hgene | SAA1 | GO:0045785 | positive regulation of cell adhesion | 9252455|11830469 |
| Hgene | SAA1 | GO:0048246 | macrophage chemotaxis | 7561109 |
| Hgene | SAA1 | GO:0048247 | lymphocyte chemotaxis | 7636186 |
| Hgene | SAA1 | GO:0050715 | positive regulation of cytokine secretion | 12857601 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP384371 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000356524 | ENST00000483017 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-3UTR | ENST00000356524 | ENST00000329146 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-3UTR | ENST00000356524 | ENST00000548989 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-intron | ENST00000532858 | ENST00000483017 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-3UTR | ENST00000532858 | ENST00000329146 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-3UTR | ENST00000532858 | ENST00000548989 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-intron | ENST00000405158 | ENST00000483017 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-3UTR | ENST00000405158 | ENST00000329146 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
| 5CDS-3UTR | ENST00000405158 | ENST00000548989 | SAA1 | chr11 | 18290850 | - | CRIP2 | chr14 | 105946164 | + |
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FusionProtFeatures for SAA1_CRIP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SAA1 | CRIP2 |