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Fusion gene ID: 32522 |
FusionGeneSummary for S1PR5_CDC37 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: S1PR5_CDC37 | Fusion gene ID: 32522 | Hgene | Tgene | Gene symbol | S1PR5 | CDC37 | Gene ID | 53637 | 11140 |
| Gene name | sphingosine-1-phosphate receptor 5 | cell division cycle 37 | |
| Synonyms | EDG8|Edg-8|S1P5|SPPR-1|SPPR-2 | P50CDC37 | |
| Cytomap | 19p13.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sphingosine 1-phosphate receptor 5S1P receptor 5S1P receptor Edg-8endothelial differentiation G-protein-coupled receptor 8endothelial differentiation, sphingolipid G-protein-coupled receptor, 8sphingosine 1-phosphate receptor EDG8sphingosine 1-phosp | hsp90 co-chaperone Cdc37CDC37 (cell division cycle 37, S. cerevisiae, homolog)CDC37 cell division cycle 37 homologcell division cycle 37 homologhsp90 chaperone protein kinase-targeting subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H228 | Q16543 | |
| Ensembl transtripts involved in fusion gene | ENST00000333430, ENST00000439028, | ENST00000222005, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 6 X 4=120 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: S1PR5 [Title/Abstract] AND CDC37 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-X6-A7WA-01A | S1PR5 | chr19 | 10628074 | - | CDC37 | chr19 | 10506879 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000333430 | ENST00000222005 | S1PR5 | chr19 | 10628074 | - | CDC37 | chr19 | 10506879 | - |
| intron-3CDS | ENST00000439028 | ENST00000222005 | S1PR5 | chr19 | 10628074 | - | CDC37 | chr19 | 10506879 | - |
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FusionProtFeatures for S1PR5_CDC37 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| S1PR5 | CDC37 |