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Fusion gene ID: 32503 |
FusionGeneSummary for S100A7A_S100A9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: S100A7A_S100A9 | Fusion gene ID: 32503 | Hgene | Tgene | Gene symbol | S100A7A | S100A9 | Gene ID | 338324 | 6280 |
| Gene name | S100 calcium binding protein A7A | S100 calcium binding protein A9 | |
| Synonyms | NICE-2|NICE2|S100A15|S100A7L1|S100A7f | 60B8AG|CAGB|CFAG|CGLB|L1AG|LIAG|MAC387|MIF|MRP14|NIF|P14 | |
| Cytomap | 1q21.3 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein S100-A7AS100 calcium-binding protein A15S100 calcium-binding protein A7-like 1koebnerisin | protein S100-A9MRP-14calgranulin Bcalprotectin L1H subunitleukocyte L1 complex heavy chainmigration inhibitory factor-related protein 14 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q86SG5 | P06702 | |
| Ensembl transtripts involved in fusion gene | ENST00000368729, ENST00000368728, ENST00000329256, | ENST00000368738, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 2=72 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: S100A7A [Title/Abstract] AND S100A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | S100A9 | GO:0002523 | leukocyte migration involved in inflammatory response | 12626582 |
| Tgene | S100A9 | GO:0006914 | autophagy | 19935772 |
| Tgene | S100A9 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 19935772 |
| Tgene | S100A9 | GO:0030593 | neutrophil chemotaxis | 12626582 |
| Tgene | S100A9 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation | 25417112 |
| Tgene | S100A9 | GO:0035821 | modification of morphology or physiology of other organism | 12874352 |
| Tgene | S100A9 | GO:0050729 | positive regulation of inflammatory response | 12626582 |
| Tgene | S100A9 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12874352 |
| Tgene | S100A9 | GO:0070488 | neutrophil aggregation | 12626582 |
| Tgene | S100A9 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 19935772 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-92-8065-01A | S100A7A | chr1 | 153390699 | + | S100A9 | chr1 | 153333120 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368729 | ENST00000368738 | S100A7A | chr1 | 153390699 | + | S100A9 | chr1 | 153333120 | + |
| In-frame | ENST00000368728 | ENST00000368738 | S100A7A | chr1 | 153390699 | + | S100A9 | chr1 | 153333120 | + |
| In-frame | ENST00000329256 | ENST00000368738 | S100A7A | chr1 | 153390699 | + | S100A9 | chr1 | 153333120 | + |
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FusionProtFeatures for S100A7A_S100A9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| S100A7A | S100A9 |