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Fusion gene ID: 32480 |
FusionGeneSummary for S100A2_CXCR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: S100A2_CXCR5 | Fusion gene ID: 32480 | Hgene | Tgene | Gene symbol | S100A2 | CXCR5 | Gene ID | 6273 | 643 |
| Gene name | S100 calcium binding protein A2 | C-X-C motif chemokine receptor 5 | |
| Synonyms | CAN19|S100L | BLR1|CD185|MDR15 | |
| Cytomap | 1q21.3 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein S100-A2 | C-X-C chemokine receptor type 5Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Burkitt lymphoma receptor 1, GTP-binding proteinCXC-R5CXCR-5MDR-15chemokine (C-X-C motif) receptor 5monocyte-derived receptor 15 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | P29034 | P32302 | |
| Ensembl transtripts involved in fusion gene | ENST00000368708, ENST00000487430, ENST00000497140, ENST00000368710, ENST00000368709, ENST00000368707, | ENST00000292174, | |
| Fusion gene scores | * DoF score | 8 X 4 X 4=128 | 11 X 3 X 7=231 |
| # samples | 10 | 11 | |
| ** MAII score | log2(10/128*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/231*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: S100A2 [Title/Abstract] AND CXCR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CV-5978-01A | S100A2 | chr1 | 153533819 | - | CXCR5 | chr11 | 118754475 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000368708 | ENST00000292174 | S100A2 | chr1 | 153533819 | - | CXCR5 | chr11 | 118754475 | + |
| Frame-shift | ENST00000487430 | ENST00000292174 | S100A2 | chr1 | 153533819 | - | CXCR5 | chr11 | 118754475 | + |
| In-frame | ENST00000497140 | ENST00000292174 | S100A2 | chr1 | 153533819 | - | CXCR5 | chr11 | 118754475 | + |
| In-frame | ENST00000368710 | ENST00000292174 | S100A2 | chr1 | 153533819 | - | CXCR5 | chr11 | 118754475 | + |
| Frame-shift | ENST00000368709 | ENST00000292174 | S100A2 | chr1 | 153533819 | - | CXCR5 | chr11 | 118754475 | + |
| In-frame | ENST00000368707 | ENST00000292174 | S100A2 | chr1 | 153533819 | - | CXCR5 | chr11 | 118754475 | + |
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FusionProtFeatures for S100A2_CXCR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| S100A2 | CXCR5 |