	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 32473

FusionGeneSummary for S100A13_MAT2B

Fusion gene summary

Fusion gene information	Fusion gene name: S100A13_MAT2B
	Fusion gene ID: 32473
		Hgene	Tgene
	Gene symbol	S100A13	MAT2B
	Gene ID	6284	27430
	Gene name	S100 calcium binding protein A13	methionine adenosyltransferase 2B
	Synonyms	-	MAT-II\|MATIIbeta\|Nbla02999\|SDR23E1\|TGR
	Cytomap	1q21.3	5q34
	Type of gene	protein-coding	protein-coding
	Description	protein S100-A13	methionine adenosyltransferase 2 subunit betaMAT II betabeta regulatory subunit of methionine adenosyltransferasedTDP-4-keto-6-deoxy-D-glucose 4-reductasemethionine adenosyltransferase II, betaputative dTDP-4-keto-6-deoxy-D-glucose 4-reductaseputati
	Modification date	20180522	20180522
	UniProtAcc	Q99584	Q9NZL9
	Ensembl transtripts involved in fusion gene	ENST00000339556, ENST00000392622, ENST00000392623, ENST00000440685, ENST00000368699, ENST00000491177,	ENST00000280969, ENST00000321757, ENST00000518095, ENST00000521838,
Fusion gene scores	* DoF score	5 X 5 X 2=50	1 X 1 X 1=1
	# samples	5	1
	** MAII score	log2(5/50*10)=0	log2(1/1*10)=3.32192809488736
Context	PubMed: S100A13 [Title/Abstract] AND MAT2B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	S100A13	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	15033494
Hgene	S100A13	GO:0050703	interleukin-1 alpha secretion	12746488
Tgene	MAT2B	GO:0006556	S-adenosylmethionine biosynthetic process	10644686\|25075345

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BP259408	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000339556	ENST00000280969	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000339556	ENST00000321757	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000339556	ENST00000518095	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-intron	ENST00000339556	ENST00000521838	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000392622	ENST00000280969	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000392622	ENST00000321757	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000392622	ENST00000518095	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-intron	ENST00000392622	ENST00000521838	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000392623	ENST00000280969	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000392623	ENST00000321757	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000392623	ENST00000518095	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-intron	ENST00000392623	ENST00000521838	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000440685	ENST00000280969	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000440685	ENST00000321757	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000440685	ENST00000518095	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-intron	ENST00000440685	ENST00000521838	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000368699	ENST00000280969	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000368699	ENST00000321757	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000368699	ENST00000518095	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-intron	ENST00000368699	ENST00000521838	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000491177	ENST00000280969	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000491177	ENST00000321757	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-3CDS	ENST00000491177	ENST00000518095	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+
intron-intron	ENST00000491177	ENST00000521838	S100A13	chr1	153604262	+	MAT2B	chr5	162939116	+

Top

FusionProtFeatures for S100A13_MAT2B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
S100A13 Q99584	MAT2B Q9NZL9

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 32473

FusionGeneSummary for S100A13_MAT2B

FusionProtFeatures for S100A13_MAT2B