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Fusion gene ID: 32466 |
FusionGeneSummary for RYR3_LARP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RYR3_LARP4 | Fusion gene ID: 32466 | Hgene | Tgene | Gene symbol | RYR3 | LARP4 | Gene ID | 6263 | 113251 |
| Gene name | ryanodine receptor 3 | La ribonucleoprotein domain family member 4 | |
| Synonyms | RYR-3 | PP13296 | |
| Cytomap | 15q13.3-q14 | 12q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ryanodine receptor 3brain ryanodine receptor-calcium release channelbrain-type ryanodine receptortype 3 ryanodine receptor | la-related protein 4c-Mpl binding protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q15413 | Q71RC2 | |
| Ensembl transtripts involved in fusion gene | ENST00000415757, ENST00000389232, ENST00000559917, | ENST00000293618, ENST00000429001, ENST00000398473, ENST00000518444, ENST00000347328, ENST00000522085, ENST00000518561, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 6 X 7 X 5=210 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RYR3 [Title/Abstract] AND LARP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A5IZ-01A | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000415757 | ENST00000293618 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000415757 | ENST00000429001 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000415757 | ENST00000398473 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000415757 | ENST00000518444 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000415757 | ENST00000347328 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000415757 | ENST00000522085 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| 5CDS-5UTR | ENST00000415757 | ENST00000518561 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000389232 | ENST00000293618 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000389232 | ENST00000429001 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000389232 | ENST00000398473 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000389232 | ENST00000518444 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000389232 | ENST00000347328 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| In-frame | ENST00000389232 | ENST00000522085 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| 5CDS-5UTR | ENST00000389232 | ENST00000518561 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| intron-3CDS | ENST00000559917 | ENST00000293618 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| intron-3CDS | ENST00000559917 | ENST00000429001 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| intron-3CDS | ENST00000559917 | ENST00000398473 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| intron-3CDS | ENST00000559917 | ENST00000518444 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| intron-3CDS | ENST00000559917 | ENST00000347328 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| intron-3CDS | ENST00000559917 | ENST00000522085 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
| intron-5UTR | ENST00000559917 | ENST00000518561 | RYR3 | chr15 | 34034645 | + | LARP4 | chr12 | 50821545 | + |
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FusionProtFeatures for RYR3_LARP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RYR3 | LARP4 |