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Fusion gene ID: 32448 |
FusionGeneSummary for RYBP_FHIT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RYBP_FHIT | Fusion gene ID: 32448 | Hgene | Tgene | Gene symbol | RYBP | FHIT | Gene ID | 23429 | 2272 |
| Gene name | RING1 and YY1 binding protein | fragile histidine triad | |
| Synonyms | AAP1|APAP-1|DEDAF|YEAF1 | AP3Aase|FRA3B | |
| Cytomap | 3p13 | 3p14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RING1 and YY1-binding proteinDED-associated factorYY1 and E4TF1 associated factor 1apoptin-associating protein 1death effector domain-associated factorring1 interactor RYBP | bis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatase | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8N488 | P49789 | |
| Ensembl transtripts involved in fusion gene | ENST00000477973, | ENST00000476844, ENST00000492590, ENST00000466788, ENST00000468189, ENST00000341848, | |
| Fusion gene scores | * DoF score | 6 X 2 X 5=60 | 17 X 7 X 10=1190 |
| # samples | 7 | 20 | |
| ** MAII score | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(20/1190*10)=-2.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RYBP [Title/Abstract] AND FHIT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RYBP | GO:0035518 | histone H2A monoubiquitination | 16943429 |
| Tgene | FHIT | GO:0006163 | purine nucleotide metabolic process | 9323207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A8IJ-01A | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| TCGA | RV | THYM | TCGA-4V-A9QJ-01A | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000477973 | ENST00000476844 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| In-frame | ENST00000477973 | ENST00000492590 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| 5CDS-5UTR | ENST00000477973 | ENST00000466788 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| 5CDS-5UTR | ENST00000477973 | ENST00000468189 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
| 5CDS-5UTR | ENST00000477973 | ENST00000341848 | RYBP | chr3 | 72495647 | - | FHIT | chr3 | 59738047 | - |
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FusionProtFeatures for RYBP_FHIT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RYBP | FHIT |