|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 32442 |
FusionGeneSummary for RXRA_WDR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RXRA_WDR5 | Fusion gene ID: 32442 | Hgene | Tgene | Gene symbol | RXRA | WDR5 | Gene ID | 6256 | 11091 |
| Gene name | retinoid X receptor alpha | WD repeat domain 5 | |
| Synonyms | NR2B1 | BIG-3|CFAP89|SWD3 | |
| Cytomap | 9q34.2 | 9q34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | retinoic acid receptor RXR-alphanuclear receptor subfamily 2 group B member 1retinoid X nuclear receptor alpha | WD repeat-containing protein 5BMP2-induced 3-kb gene proteinSWD3, Set1c WD40 repeat protein, homologcilia and flagella associated protein 89 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P19793 | P61964 | |
| Ensembl transtripts involved in fusion gene | ENST00000481739, ENST00000356384, ENST00000540193, | ENST00000358625, ENST00000425041, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 2 X 2 X 1=4 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: RXRA [Title/Abstract] AND WDR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RXRA | GO:0000122 | negative regulation of transcription by RNA polymerase II | 17426122 |
| Hgene | RXRA | GO:0019048 | modulation by virus of host morphology or physiology | 11915042 |
| Hgene | RXRA | GO:0035357 | peroxisome proliferator activated receptor signaling pathway | 10195690 |
| Hgene | RXRA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12037571|20219900 |
| Hgene | RXRA | GO:0051289 | protein homotetramerization | 7831303 |
| Tgene | WDR5 | GO:0043966 | histone H3 acetylation | 18838386 |
| Tgene | WDR5 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Tgene | WDR5 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Tgene | WDR5 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Tgene | WDR5 | GO:0051568 | histone H3-K4 methylation | 17355966|19556245 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-2Y-A9GZ-01A | RXRA | chr9 | 137218505 | + | WDR5 | chr9 | 137017105 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000481739 | ENST00000358625 | RXRA | chr9 | 137218505 | + | WDR5 | chr9 | 137017105 | + |
| Frame-shift | ENST00000481739 | ENST00000425041 | RXRA | chr9 | 137218505 | + | WDR5 | chr9 | 137017105 | + |
| intron-3CDS | ENST00000356384 | ENST00000358625 | RXRA | chr9 | 137218505 | + | WDR5 | chr9 | 137017105 | + |
| intron-3CDS | ENST00000356384 | ENST00000425041 | RXRA | chr9 | 137218505 | + | WDR5 | chr9 | 137017105 | + |
| intron-3CDS | ENST00000540193 | ENST00000358625 | RXRA | chr9 | 137218505 | + | WDR5 | chr9 | 137017105 | + |
| intron-3CDS | ENST00000540193 | ENST00000425041 | RXRA | chr9 | 137218505 | + | WDR5 | chr9 | 137017105 | + |
Top |
FusionProtFeatures for RXRA_WDR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RXRA | WDR5 |