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Fusion gene ID: 32364 |
FusionGeneSummary for RTN4_ANAPC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RTN4_ANAPC4 | Fusion gene ID: 32364 | Hgene | Tgene | Gene symbol | RTN4 | ANAPC4 | Gene ID | 57142 | 29945 |
| Gene name | reticulon 4 | anaphase promoting complex subunit 4 | |
| Synonyms | ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C | APC4 | |
| Cytomap | 2p16.1 | 4p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5 | anaphase-promoting complex subunit 4cyclosome subunit 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NQC3 | Q9UJX5 | |
| Ensembl transtripts involved in fusion gene | ENST00000394609, ENST00000405240, ENST00000357376, ENST00000317610, ENST00000357732, ENST00000337526, ENST00000394611, ENST00000404909, ENST00000486085, ENST00000354474, ENST00000402434, | ENST00000315368, ENST00000510092, | |
| Fusion gene scores | * DoF score | 8 X 15 X 4=480 | 2 X 2 X 2=8 |
| # samples | 18 | 2 | |
| ** MAII score | log2(18/480*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RTN4 [Title/Abstract] AND ANAPC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RTN4 | GO:0030517 | negative regulation of axon extension | 10667797 |
| Hgene | RTN4 | GO:0071787 | endoplasmic reticulum tubular network formation | 24262037|25612671 |
| Hgene | RTN4 | GO:1905552 | positive regulation of protein localization to endoplasmic reticulum | 27353365 |
| Tgene | ANAPC4 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | W68781 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000394609 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000394609 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000405240 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000405240 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000357376 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000357376 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000317610 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000317610 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000357732 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000357732 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000337526 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000337526 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000394611 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000394611 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000404909 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000404909 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000486085 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000486085 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000354474 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000354474 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000402434 | ENST00000315368 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
| intron-3CDS | ENST00000402434 | ENST00000510092 | RTN4 | chr2 | 55209717 | - | ANAPC4 | chr4 | 25419961 | + |
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FusionProtFeatures for RTN4_ANAPC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RTN4 | ANAPC4 |