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Fusion gene ID: 32361 |
FusionGeneSummary for RTN4RL2_P2RX3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RTN4RL2_P2RX3 | Fusion gene ID: 32361 | Hgene | Tgene | Gene symbol | RTN4RL2 | P2RX3 | Gene ID | 349667 | 5024 |
| Gene name | reticulon 4 receptor like 2 | purinergic receptor P2X 3 | |
| Synonyms | NGRH1|NgR2 | P2X3 | |
| Cytomap | 11q12.1 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | reticulon-4 receptor-like 2Nogo-66 receptor homolog 1nogo receptor-like 3nogo-66 receptor-related protein 2 | P2X purinoceptor 3ATP receptorP2X receptor, subunit 3purinergic receptor P2X, ligand gated ion channel, 3purinergic receptor P2X3purinoceptor P2X3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86UN3 | P56373 | |
| Ensembl transtripts involved in fusion gene | ENST00000335099, ENST00000533205, ENST00000395120, | ENST00000533436, ENST00000263314, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RTN4RL2 [Title/Abstract] AND P2RX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A3TO-01A | RTN4RL2 | chr11 | 57235563 | + | P2RX3 | chr11 | 57135483 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000335099 | ENST00000533436 | RTN4RL2 | chr11 | 57235563 | + | P2RX3 | chr11 | 57135483 | + |
| 5CDS-intron | ENST00000335099 | ENST00000263314 | RTN4RL2 | chr11 | 57235563 | + | P2RX3 | chr11 | 57135483 | + |
| 5CDS-intron | ENST00000533205 | ENST00000533436 | RTN4RL2 | chr11 | 57235563 | + | P2RX3 | chr11 | 57135483 | + |
| 5CDS-intron | ENST00000533205 | ENST00000263314 | RTN4RL2 | chr11 | 57235563 | + | P2RX3 | chr11 | 57135483 | + |
| 5CDS-intron | ENST00000395120 | ENST00000533436 | RTN4RL2 | chr11 | 57235563 | + | P2RX3 | chr11 | 57135483 | + |
| 5CDS-intron | ENST00000395120 | ENST00000263314 | RTN4RL2 | chr11 | 57235563 | + | P2RX3 | chr11 | 57135483 | + |
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FusionProtFeatures for RTN4RL2_P2RX3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RTN4RL2 | P2RX3 |