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Fusion gene ID: 32246 |
FusionGeneSummary for RREB1_WRN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RREB1_WRN | Fusion gene ID: 32246 | Hgene | Tgene | Gene symbol | RREB1 | WRN | Gene ID | 6239 | 7486 |
| Gene name | ras responsive element binding protein 1 | Werner syndrome RecQ like helicase | |
| Synonyms | FINB|HNT|LZ321|RREB-1|Zep-1 | RECQ3|RECQL2|RECQL3 | |
| Cytomap | 6p24.3 | 8p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1 | Werner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q92766 | Q14191 | |
| Ensembl transtripts involved in fusion gene | ENST00000379933, ENST00000379938, ENST00000334984, ENST00000349384, | ENST00000298139, | |
| Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 6 X 5 X 5=150 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/594*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RREB1 [Title/Abstract] AND WRN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8816445 |
| Tgene | WRN | GO:0000731 | DNA synthesis involved in DNA repair | 17563354 |
| Tgene | WRN | GO:0006259 | DNA metabolic process | 16622405 |
| Tgene | WRN | GO:0006284 | base-excision repair | 17611195 |
| Tgene | WRN | GO:0006974 | cellular response to DNA damage stimulus | 18203716 |
| Tgene | WRN | GO:0006979 | response to oxidative stress | 17611195 |
| Tgene | WRN | GO:0009267 | cellular response to starvation | 11420665 |
| Tgene | WRN | GO:0010225 | response to UV-C | 17563354 |
| Tgene | WRN | GO:0031297 | replication fork processing | 17115688 |
| Tgene | WRN | GO:0032508 | DNA duplex unwinding | 11735402|26420422 |
| Tgene | WRN | GO:0044806 | G-quadruplex DNA unwinding | 11735402 |
| Tgene | WRN | GO:0051345 | positive regulation of hydrolase activity | 17611195 |
| Tgene | WRN | GO:0061820 | telomeric D-loop disassembly | 15200954|19734539|26420422 |
| Tgene | WRN | GO:0071480 | cellular response to gamma radiation | 21639834 |
| Tgene | WRN | GO:0098530 | positive regulation of strand invasion | 26420422 |
| Tgene | WRN | GO:1902570 | protein localization to nucleolus | 11420665 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU607882 | RREB1 | chr6 | 7252213 | + | WRN | chr8 | 30989496 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000379933 | ENST00000298139 | RREB1 | chr6 | 7252213 | + | WRN | chr8 | 30989496 | - |
| 5CDS-intron | ENST00000379938 | ENST00000298139 | RREB1 | chr6 | 7252213 | + | WRN | chr8 | 30989496 | - |
| intron-intron | ENST00000334984 | ENST00000298139 | RREB1 | chr6 | 7252213 | + | WRN | chr8 | 30989496 | - |
| intron-intron | ENST00000349384 | ENST00000298139 | RREB1 | chr6 | 7252213 | + | WRN | chr8 | 30989496 | - |
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FusionProtFeatures for RREB1_WRN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RREB1 | WRN |