|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 32240 |
FusionGeneSummary for RREB1_KIFAP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RREB1_KIFAP3 | Fusion gene ID: 32240 | Hgene | Tgene | Gene symbol | RREB1 | KIFAP3 | Gene ID | 6239 | 22920 |
| Gene name | ras responsive element binding protein 1 | kinesin associated protein 3 | |
| Synonyms | FINB|HNT|LZ321|RREB-1|Zep-1 | FLA3|KAP-1|KAP-3|KAP3|SMAP|Smg-GDS|dJ190I16.1 | |
| Cytomap | 6p24.3 | 1q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1 | kinesin-associated protein 3small G protein GDP dissociation stimulatorsmg GDS-associated protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q92766 | Q92845 | |
| Ensembl transtripts involved in fusion gene | ENST00000379933, ENST00000379938, ENST00000334984, ENST00000349384, | ENST00000367765, ENST00000367767, ENST00000361580, ENST00000538366, ENST00000540905, ENST00000490550, | |
| Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 6 X 6 X 6=216 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/594*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RREB1 [Title/Abstract] AND KIFAP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8816445 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU679959 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000379933 | ENST00000367765 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000379933 | ENST00000367767 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000379933 | ENST00000361580 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000379933 | ENST00000538366 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000379933 | ENST00000540905 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000379933 | ENST00000490550 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| 3UTR-intron | ENST00000379938 | ENST00000367765 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| 3UTR-intron | ENST00000379938 | ENST00000367767 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| 3UTR-intron | ENST00000379938 | ENST00000361580 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| 3UTR-intron | ENST00000379938 | ENST00000538366 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| 3UTR-intron | ENST00000379938 | ENST00000540905 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| 3UTR-intron | ENST00000379938 | ENST00000490550 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000334984 | ENST00000367765 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000334984 | ENST00000367767 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000334984 | ENST00000361580 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000334984 | ENST00000538366 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000334984 | ENST00000540905 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000334984 | ENST00000490550 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000349384 | ENST00000367765 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000349384 | ENST00000367767 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000349384 | ENST00000361580 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000349384 | ENST00000538366 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000349384 | ENST00000540905 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
| intron-intron | ENST00000349384 | ENST00000490550 | RREB1 | chr6 | 7252147 | - | KIFAP3 | chr1 | 170003513 | + |
Top |
FusionProtFeatures for RREB1_KIFAP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RREB1 | KIFAP3 |