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Fusion gene ID: 32175 |
FusionGeneSummary for RPS6_MAP2K1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS6_MAP2K1 | Fusion gene ID: 32175 | Hgene | Tgene | Gene symbol | RPS6 | MAP2K1 | Gene ID | 6194 | 5604 |
| Gene name | ribosomal protein S6 | mitogen-activated protein kinase kinase 1 | |
| Synonyms | S6 | CFC3|MAPKK1|MEK1|MKK1|PRKMK1 | |
| Cytomap | 9p22.1 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 40S ribosomal protein S6phosphoprotein NP33small ribosomal subunit protein eS6 | dual specificity mitogen-activated protein kinase kinase 1ERK activator kinase 1MAPK/ERK kinase 1MAPKK 1MEK 1protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P62753 | Q02750 | |
| Ensembl transtripts involved in fusion gene | ENST00000380394, ENST00000498815, ENST00000380384, ENST00000315377, ENST00000380381, | ENST00000307102, ENST00000566326, | |
| Fusion gene scores | * DoF score | 14 X 14 X 2=392 | 2 X 2 X 2=8 |
| # samples | 18 | 2 | |
| ** MAII score | log2(18/392*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RPS6 [Title/Abstract] AND MAP2K1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPS6 | GO:0031929 | TOR signaling | 16428328 |
| Hgene | RPS6 | GO:0043065 | positive regulation of apoptotic process | 18362888 |
| Tgene | MAP2K1 | GO:0000187 | activation of MAPK activity | 10644344 |
| Tgene | MAP2K1 | GO:0006468 | protein phosphorylation | 28166211 |
| Tgene | MAP2K1 | GO:0008285 | negative regulation of cell proliferation | 9765203 |
| Tgene | MAP2K1 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8388392 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD520454 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000380394 | ENST00000307102 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000380394 | ENST00000566326 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000498815 | ENST00000307102 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000498815 | ENST00000566326 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000380384 | ENST00000307102 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000380384 | ENST00000566326 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000315377 | ENST00000307102 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000315377 | ENST00000566326 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000380381 | ENST00000307102 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
| intron-intron | ENST00000380381 | ENST00000566326 | RPS6 | chr9 | 19378437 | - | MAP2K1 | chr15 | 66738825 | - |
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FusionProtFeatures for RPS6_MAP2K1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS6 | MAP2K1 |