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Fusion gene ID: 32160 |
FusionGeneSummary for RPS6KB2_PCNXL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS6KB2_PCNXL3 | Fusion gene ID: 32160 | Hgene | Tgene | Gene symbol | RPS6KB2 | PCNXL3 | Gene ID | 6199 | 399909 |
| Gene name | ribosomal protein S6 kinase B2 | pecanex homolog 3 | |
| Synonyms | KLS|P70-beta|P70-beta-1|P70-beta-2|S6K-beta2|S6K2|S6KB|S6KI(2)|S6Kbeta|SRK|STK14B|p70(S6K)-beta|p70S6Kb | PCNXL3 | |
| Cytomap | 11q13.2 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ribosomal protein S6 kinase beta-270 kDa ribosomal protein S6 kinase 2P70S6K2S6 kinase-related kinaseS6K-betaS6K-beta-2p70 S6 kinase betap70 S6K-betap70 S6KBp70 ribosomal S6 kinase betap70-S6K 2ribosomal protein S6 kinase, 70kDa, polypeptide 2 | pecanex-like protein 3pecanex homolog protein 3pecanex-like 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UBS0 | ||
| Ensembl transtripts involved in fusion gene | ENST00000524814, ENST00000539188, ENST00000312629, | ENST00000355703, ENST00000531280, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RPS6KB2 [Title/Abstract] AND PCNXL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-F7-7848-01A | RPS6KB2 | chr11 | 67196711 | + | PCNXL3 | chr11 | 65385411 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000524814 | ENST00000355703 | RPS6KB2 | chr11 | 67196711 | + | PCNXL3 | chr11 | 65385411 | + |
| 3UTR-intron | ENST00000524814 | ENST00000531280 | RPS6KB2 | chr11 | 67196711 | + | PCNXL3 | chr11 | 65385411 | + |
| Frame-shift | ENST00000539188 | ENST00000355703 | RPS6KB2 | chr11 | 67196711 | + | PCNXL3 | chr11 | 65385411 | + |
| 5CDS-intron | ENST00000539188 | ENST00000531280 | RPS6KB2 | chr11 | 67196711 | + | PCNXL3 | chr11 | 65385411 | + |
| Frame-shift | ENST00000312629 | ENST00000355703 | RPS6KB2 | chr11 | 67196711 | + | PCNXL3 | chr11 | 65385411 | + |
| 5CDS-intron | ENST00000312629 | ENST00000531280 | RPS6KB2 | chr11 | 67196711 | + | PCNXL3 | chr11 | 65385411 | + |
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FusionProtFeatures for RPS6KB2_PCNXL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS6KB2 | PCNXL3 |