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Fusion gene ID: 32154

FusionGeneSummary for RPS6KB1_RNF213

Fusion gene summary

Fusion gene information	Fusion gene name: RPS6KB1_RNF213
	Fusion gene ID: 32154
		Hgene	Tgene
	Gene symbol	RPS6KB1	RNF213
	Gene ID	6198	57674
	Gene name	ribosomal protein S6 kinase B1	ring finger protein 213
	Synonyms	PS6K\|S6K\|S6K-beta-1\|S6K1\|STK14A\|p70 S6KA\|p70(S6K)-alpha\|p70-S6K\|p70-alpha	ALO17\|C17orf27\|KIAA1618\|MYMY2\|MYSTR\|NET57
	Cytomap	17q23.1	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	ribosomal protein S6 kinase beta-1p70 S6 kinase, alpharibosomal protein S6 kinase Iribosomal protein S6 kinase, 70kDa, polypeptide 1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14A	E3 ubiquitin-protein ligase RNF213ALK lymphoma oligomerization partner on chromosome 17RING-type E3 ubiquitin transferase RNF213mysterin
	Modification date	20180523	20180527
	UniProtAcc	P23443	Q63HN8
	Ensembl transtripts involved in fusion gene	ENST00000443572, ENST00000406116, ENST00000225577, ENST00000393021, ENST00000587061,	ENST00000508628, ENST00000456466, ENST00000582970, ENST00000319921, ENST00000336301, ENST00000427003,
Fusion gene scores	* DoF score	8 X 5 X 4=160	12 X 13 X 6=936
	# samples	8	15
	** MAII score	log2(8/160*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/936*10)=-2.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RPS6KB1 [Title/Abstract] AND RNF213 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPS6KB1	GO:0031929	TOR signaling	12150926
Hgene	RPS6KB1	GO:0071363	cellular response to growth factor stimulus	17936702
Tgene	RNF213	GO:0016567	protein ubiquitination	21799892
Tgene	RNF213	GO:0051260	protein homooligomerization	24658080\|26126547
Tgene	RNF213	GO:0051865	protein autoubiquitination	21799892

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-AQ-A04H-01B	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000443572	ENST00000508628	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000443572	ENST00000456466	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000443572	ENST00000582970	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000443572	ENST00000319921	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000443572	ENST00000336301	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000443572	ENST00000427003	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-3CDS	ENST00000406116	ENST00000508628	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000406116	ENST00000456466	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000406116	ENST00000582970	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000406116	ENST00000319921	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000406116	ENST00000336301	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000406116	ENST00000427003	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-3CDS	ENST00000225577	ENST00000508628	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000225577	ENST00000456466	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000225577	ENST00000582970	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000225577	ENST00000319921	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000225577	ENST00000336301	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000225577	ENST00000427003	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
5UTR-3CDS	ENST00000393021	ENST00000508628	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
5UTR-intron	ENST00000393021	ENST00000456466	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
5UTR-intron	ENST00000393021	ENST00000582970	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
5UTR-intron	ENST00000393021	ENST00000319921	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
5UTR-intron	ENST00000393021	ENST00000336301	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
5UTR-intron	ENST00000393021	ENST00000427003	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-3CDS	ENST00000587061	ENST00000508628	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000587061	ENST00000456466	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000587061	ENST00000582970	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000587061	ENST00000319921	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000587061	ENST00000336301	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+
intron-intron	ENST00000587061	ENST00000427003	RPS6KB1	chr17	57971285	+	RNF213	chr17	78345674	+

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FusionProtFeatures for RPS6KB1_RNF213

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RPS6KB1 P23443	RNF213 Q63HN8

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Fusion gene ID: 32154

FusionGeneSummary for RPS6KB1_RNF213

FusionProtFeatures for RPS6KB1_RNF213