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Fusion gene ID: 32098 |
FusionGeneSummary for RPS25_STK4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS25_STK4 | Fusion gene ID: 32098 | Hgene | Tgene | Gene symbol | RPS25 | STK4 | Gene ID | 6230 | 6789 |
| Gene name | ribosomal protein S25 | serine/threonine kinase 4 | |
| Synonyms | S25 | KRS2|MST1|YSK3 | |
| Cytomap | 11q23.3 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 40S ribosomal protein S25small ribosomal subunit protein eS25 | serine/threonine-protein kinase 4STE20-like kinase MST1kinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P62851 | Q13043 | |
| Ensembl transtripts involved in fusion gene | ENST00000527673, ENST00000528547, | ENST00000372806, ENST00000396731, ENST00000372801, ENST00000499879, ENST00000487587, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPS25 [Title/Abstract] AND STK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STK4 | GO:0000902 | cell morphogenesis | 11805089 |
| Tgene | STK4 | GO:0001934 | positive regulation of protein phosphorylation | 19962960 |
| Tgene | STK4 | GO:0006468 | protein phosphorylation | 8566796|11805089 |
| Tgene | STK4 | GO:0006915 | apoptotic process | 21212262 |
| Tgene | STK4 | GO:0018105 | peptidyl-serine phosphorylation | 16751106 |
| Tgene | STK4 | GO:0032092 | positive regulation of protein binding | 22292086 |
| Tgene | STK4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19962960 |
| Tgene | STK4 | GO:0035329 | hippo signaling | 20412773 |
| Tgene | STK4 | GO:0035556 | intracellular signal transduction | 8566796 |
| Tgene | STK4 | GO:0043065 | positive regulation of apoptotic process | 15109305 |
| Tgene | STK4 | GO:0046777 | protein autophosphorylation | 11805089 |
| Tgene | STK4 | GO:0050821 | protein stabilization | 19962960 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP271042 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000527673 | ENST00000372806 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000396731 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000372801 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000499879 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000527673 | ENST00000487587 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-3UTR | ENST00000528547 | ENST00000372806 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000396731 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000372801 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000499879 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
| intron-intron | ENST00000528547 | ENST00000487587 | RPS25 | chr11 | 118888201 | - | STK4 | chr20 | 43707835 | + |
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FusionProtFeatures for RPS25_STK4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS25 | STK4 |