|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 32060 |
FusionGeneSummary for RPS15A_ARL6IP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPS15A_ARL6IP1 | Fusion gene ID: 32060 | Hgene | Tgene | Gene symbol | RPS15A | ARL6IP1 | Gene ID | 6210 | 23204 |
| Gene name | ribosomal protein S15a | ADP ribosylation factor like GTPase 6 interacting protein 1 | |
| Synonyms | S15a | AIP1|ARL6IP|ARMER|SPG61 | |
| Cytomap | 16p12.3 | 16p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 40S ribosomal protein S15asmall ribosomal subunit protein uS8up-regulated by HBV X protein | ADP-ribosylation factor-like protein 6-interacting protein 1ADP-ribosylation factor GTPase 6 interacting protein 1ADP-ribosylation factor-like 6 interacting protein 1ARL-6-interacting protein 1aip-1apoptotic regulator in the membrane of the endoplasm | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P62244 | Q15041 | |
| Ensembl transtripts involved in fusion gene | ENST00000322989, ENST00000563390, ENST00000575669, ENST00000576436, ENST00000565420, ENST00000569083, | ENST00000304414, ENST00000546206, ENST00000562819, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RPS15A [Title/Abstract] AND ARL6IP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPS15A | GO:0008284 | positive regulation of cell proliferation | 15108328 |
| Hgene | RPS15A | GO:0009615 | response to virus | 15108328 |
| Hgene | RPS15A | GO:0045787 | positive regulation of cell cycle | 15108328 |
| Tgene | ARL6IP1 | GO:0043066 | negative regulation of apoptotic process | 12754298 |
| Tgene | ARL6IP1 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 12754298 |
| Tgene | ARL6IP1 | GO:0071787 | endoplasmic reticulum tubular network formation | 24262037 |
| Tgene | ARL6IP1 | GO:1990809 | endoplasmic reticulum tubular network membrane organization | 24262037 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A0D2-01A | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000322989 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| 5CDS-5UTR | ENST00000322989 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| 5CDS-5UTR | ENST00000322989 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| Frame-shift | ENST00000563390 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| 5CDS-5UTR | ENST00000563390 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| 5CDS-5UTR | ENST00000563390 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-3CDS | ENST00000575669 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-5UTR | ENST00000575669 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-5UTR | ENST00000575669 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-3CDS | ENST00000576436 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-5UTR | ENST00000576436 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-5UTR | ENST00000576436 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| Frame-shift | ENST00000565420 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| 5CDS-5UTR | ENST00000565420 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| 5CDS-5UTR | ENST00000565420 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-3CDS | ENST00000569083 | ENST00000304414 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-5UTR | ENST00000569083 | ENST00000546206 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
| intron-5UTR | ENST00000569083 | ENST00000562819 | RPS15A | chr16 | 18796060 | - | ARL6IP1 | chr16 | 18810156 | - |
Top |
FusionProtFeatures for RPS15A_ARL6IP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPS15A | ARL6IP1 |