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Fusion gene ID: 31972 |
FusionGeneSummary for RPL8_SCARB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPL8_SCARB1 | Fusion gene ID: 31972 | Hgene | Tgene | Gene symbol | RPL8 | SCARB1 | Gene ID | 6132 | 949 |
| Gene name | ribosomal protein L8 | scavenger receptor class B member 1 | |
| Synonyms | L8 | CD36L1|CLA-1|CLA1|HDLQTL6|SR-BI|SRB1 | |
| Cytomap | 8q24.3 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 60S ribosomal protein L8large ribosomal subunit protein uL2 | scavenger receptor class B member 1CD36 and LIMPII analogous 1CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1scavenger receptor class B type III | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | P62917 | Q8WTV0 | |
| Ensembl transtripts involved in fusion gene | ENST00000529163, ENST00000394920, ENST00000527914, ENST00000262584, ENST00000528957, | ENST00000339570, ENST00000415380, ENST00000261693, ENST00000376788, ENST00000546215, ENST00000535005, ENST00000541205, ENST00000540495, ENST00000544327, | |
| Fusion gene scores | * DoF score | 15 X 6 X 8=720 | 3 X 7 X 9=189 |
| # samples | 15 | 13 | |
| ** MAII score | log2(15/720*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/189*10)=-0.539874611192618 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPL8 [Title/Abstract] AND SCARB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPL8 | GO:0002181 | cytoplasmic translation | 25957688 |
| Tgene | SCARB1 | GO:0010886 | positive regulation of cholesterol storage | 9211901 |
| Tgene | SCARB1 | GO:0015920 | lipopolysaccharide transport | 12651854 |
| Tgene | SCARB1 | GO:0032497 | detection of lipopolysaccharide | 12651854 |
| Tgene | SCARB1 | GO:0034384 | high-density lipoprotein particle clearance | 9211901 |
| Tgene | SCARB1 | GO:0043654 | recognition of apoptotic cell | 9211901 |
| Tgene | SCARB1 | GO:0051000 | positive regulation of nitric-oxide synthase activity | 11792700 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5512-01A | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000529163 | ENST00000339570 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000415380 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000261693 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000376788 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000546215 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000535005 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000541205 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000540495 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000529163 | ENST00000544327 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000339570 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000415380 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000261693 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000376788 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000546215 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000535005 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000541205 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000540495 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000394920 | ENST00000544327 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000339570 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000415380 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000261693 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000376788 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000546215 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000535005 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000541205 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000540495 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000527914 | ENST00000544327 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000339570 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000415380 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000261693 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000376788 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000546215 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000535005 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000541205 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000540495 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| 5CDS-intron | ENST00000262584 | ENST00000544327 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000339570 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000415380 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000261693 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000376788 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000546215 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000535005 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000541205 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000540495 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
| intron-intron | ENST00000528957 | ENST00000544327 | RPL8 | chr8 | 146015154 | - | SCARB1 | chr12 | 125324217 | - |
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FusionProtFeatures for RPL8_SCARB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPL8 | SCARB1 |