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Fusion gene ID: 31959

FusionGeneSummary for RPL7L1_UBR2

Fusion gene summary

Fusion gene information	Fusion gene name: RPL7L1_UBR2
	Fusion gene ID: 31959
		Hgene	Tgene
	Gene symbol	RPL7L1	UBR2
	Gene ID	285855	23304
	Gene name	ribosomal protein L7 like 1	ubiquitin protein ligase E3 component n-recognin 2
	Synonyms	dJ475N16.4	C6orf133\|bA49A4.1\|dJ242G1.1\|dJ392M17.3
	Cytomap	6p21.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	60S ribosomal protein L7-like 1large ribosomal subunit protein uL30-like 1	E3 ubiquitin-protein ligase UBR2RING-type E3 ubiquitin transferase UBR2ubiquitin-protein ligase E3-alpha-2ubiquitin-protein ligase E3-alpha-II
	Modification date	20180523	20180529
	UniProtAcc	Q6DKI1	Q8IWV8
	Ensembl transtripts involved in fusion gene	ENST00000493763, ENST00000397415, ENST00000304734, ENST00000424341, ENST00000602561,	ENST00000372899, ENST00000372901, ENST00000372883, ENST00000372903,
Fusion gene scores	* DoF score	5 X 4 X 4=80	9 X 9 X 8=648
	# samples	5	11
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/648*10)=-2.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RPL7L1 [Title/Abstract] AND UBR2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UBR2	GO:0071233	cellular response to leucine	20298436

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	SKCM	TCGA-YG-AA3P-06A	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000493763	ENST00000372899	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
Frame-shift	ENST00000493763	ENST00000372901	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-3UTR	ENST00000493763	ENST00000372883	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-intron	ENST00000493763	ENST00000372903	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
3UTR-3CDS	ENST00000397415	ENST00000372899	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
3UTR-3CDS	ENST00000397415	ENST00000372901	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
3UTR-3UTR	ENST00000397415	ENST00000372883	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
3UTR-intron	ENST00000397415	ENST00000372903	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
Frame-shift	ENST00000304734	ENST00000372899	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
Frame-shift	ENST00000304734	ENST00000372901	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-3UTR	ENST00000304734	ENST00000372883	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-intron	ENST00000304734	ENST00000372903	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
Frame-shift	ENST00000424341	ENST00000372899	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
Frame-shift	ENST00000424341	ENST00000372901	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-3UTR	ENST00000424341	ENST00000372883	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-intron	ENST00000424341	ENST00000372903	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
Frame-shift	ENST00000602561	ENST00000372899	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
Frame-shift	ENST00000602561	ENST00000372901	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-3UTR	ENST00000602561	ENST00000372883	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+
5CDS-intron	ENST00000602561	ENST00000372903	RPL7L1	chr6	42848704	+	UBR2	chr6	42650793	+

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FusionProtFeatures for RPL7L1_UBR2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RPL7L1 Q6DKI1	UBR2 Q8IWV8

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Fusion gene ID: 31959

FusionGeneSummary for RPL7L1_UBR2

FusionProtFeatures for RPL7L1_UBR2