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Fusion gene ID: 31897 |
FusionGeneSummary for RPL35_NOC2L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPL35_NOC2L | Fusion gene ID: 31897 | Hgene | Tgene | Gene symbol | RPL35 | NOC2L | Gene ID | 11224 | 26155 |
| Gene name | ribosomal protein L35 | NOC2 like nucleolar associated transcriptional repressor | |
| Synonyms | L35 | NET15|NET7|NIR|PPP1R112 | |
| Cytomap | 9q33.3 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 60S ribosomal protein L35large ribosomal subunit protein uL29 | nucleolar complex protein 2 homologNOC2-like proteinNOC2L nucleolar associated transcriptional repressornovel INHAT (inhibitor of histone acetyltransferase) repressornovel INHAT repressornucleolar complex associated 2 homologprotein NOC2 homologpro | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P42766 | Q9Y3T9 | |
| Ensembl transtripts involved in fusion gene | ENST00000373570, ENST00000348462, | ENST00000327044, ENST00000487214, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RPL35 [Title/Abstract] AND NOC2L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NOC2L | GO:0000122 | negative regulation of transcription by RNA polymerase II | 20123734|20959462 |
| Tgene | NOC2L | GO:0031497 | chromatin assembly | 16322561 |
| Tgene | NOC2L | GO:0034644 | cellular response to UV | 20959462 |
| Tgene | NOC2L | GO:0035067 | negative regulation of histone acetylation | 16322561 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA433490 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000373570 | ENST00000327044 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| intron-5UTR | ENST00000373570 | ENST00000487214 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| intron-3CDS | ENST00000348462 | ENST00000327044 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
| intron-5UTR | ENST00000348462 | ENST00000487214 | RPL35 | chr9 | 127620282 | + | NOC2L | chr1 | 892529 | + |
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FusionProtFeatures for RPL35_NOC2L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPL35 | NOC2L |