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Fusion gene ID: 31861

FusionGeneSummary for RPL28_C22orf23

Fusion gene summary

Fusion gene information	Fusion gene name: RPL28_C22orf23
	Fusion gene ID: 31861
		Hgene	Tgene
	Gene symbol	RPL28	C22orf23
	Gene ID	6158	84645
	Gene name	ribosomal protein L28	chromosome 22 open reading frame 23
	Synonyms	L28	EVG1\|dJ1039K5.6
	Cytomap	19q13.42	22q13.1
	Type of gene	protein-coding	protein-coding
	Description	60S ribosomal protein L28large ribosomal subunit protein eL28	UPF0193 protein EVG1
	Modification date	20180525	20180519
	UniProtAcc	P46779	Q9BZE7
	Ensembl transtripts involved in fusion gene	ENST00000344063, ENST00000431533, ENST00000428193, ENST00000558815, ENST00000560583, ENST00000560055, ENST00000559463, ENST00000558131, ENST00000558752, ENST00000458349,	ENST00000403305, ENST00000249079, ENST00000403026,
Fusion gene scores	* DoF score	9 X 9 X 2=162	3 X 3 X 3=27
	# samples	11	3
	** MAII score	log2(11/162*10)=-0.558490289359965 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RPL28 [Title/Abstract] AND C22orf23 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DB253394	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000344063	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000344063	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-intron	ENST00000344063	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-3UTR	ENST00000431533	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-3UTR	ENST00000431533	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-intron	ENST00000431533	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-3UTR	ENST00000428193	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-3UTR	ENST00000428193	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-intron	ENST00000428193	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000558815	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000558815	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-intron	ENST00000558815	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000560583	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000560583	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-intron	ENST00000560583	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000560055	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000560055	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-intron	ENST00000560055	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000559463	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000559463	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-intron	ENST00000559463	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
3UTR-3UTR	ENST00000558131	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
3UTR-3UTR	ENST00000558131	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
3UTR-intron	ENST00000558131	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-3UTR	ENST00000558752	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-3UTR	ENST00000558752	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
intron-intron	ENST00000558752	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000458349	ENST00000403305	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-3UTR	ENST00000458349	ENST00000249079	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+
5CDS-intron	ENST00000458349	ENST00000403026	RPL28	chr19	55899410	+	C22orf23	chr22	38340103	+

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FusionProtFeatures for RPL28_C22orf23

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RPL28 P46779	C22orf23 Q9BZE7

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Fusion gene ID: 31861

FusionGeneSummary for RPL28_C22orf23

FusionProtFeatures for RPL28_C22orf23