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Fusion gene ID: 31822 |
FusionGeneSummary for RPL18_SQSTM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPL18_SQSTM1 | Fusion gene ID: 31822 | Hgene | Tgene | Gene symbol | RPL18 | SQSTM1 | Gene ID | 6141 | 8878 |
| Gene name | ribosomal protein L18 | sequestosome 1 | |
| Synonyms | L18 | A170|DMRV|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62B | |
| Cytomap | 19q13.33 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 60S ribosomal protein L18large ribosomal subunit protein eL18 | sequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPoxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDaubiquitin-bi | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q07020 | Q13501 | |
| Ensembl transtripts involved in fusion gene | ENST00000549920, ENST00000550645, ENST00000552588, ENST00000549273, | ENST00000376929, ENST00000506690, ENST00000389805, ENST00000402874, ENST00000510187, ENST00000360718, | |
| Fusion gene scores | * DoF score | 20 X 12 X 6=1440 | 17 X 12 X 8=1632 |
| # samples | 21 | 23 | |
| ** MAII score | log2(21/1440*10)=-2.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/1632*10)=-2.82693529102712 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPL18 [Title/Abstract] AND SQSTM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RPL18 | GO:0002181 | cytoplasmic translation | 25957688 |
| Tgene | SQSTM1 | GO:0007032 | endosome organization | 27368102 |
| Tgene | SQSTM1 | GO:0061635 | regulation of protein complex stability | 25127057 |
| Tgene | SQSTM1 | GO:1905719 | protein localization to perinuclear region of cytoplasm | 27368102 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-J9-A8CN-01A | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000549920 | ENST00000376929 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000549920 | ENST00000506690 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000549920 | ENST00000389805 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000549920 | ENST00000402874 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000549920 | ENST00000510187 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000549920 | ENST00000360718 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| Frame-shift | ENST00000550645 | ENST00000376929 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000550645 | ENST00000506690 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000550645 | ENST00000389805 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000550645 | ENST00000402874 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000550645 | ENST00000510187 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000550645 | ENST00000360718 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| Frame-shift | ENST00000552588 | ENST00000376929 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000552588 | ENST00000506690 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000552588 | ENST00000389805 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000552588 | ENST00000402874 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000552588 | ENST00000510187 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| 5CDS-intron | ENST00000552588 | ENST00000360718 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| intron-3CDS | ENST00000549273 | ENST00000376929 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| intron-intron | ENST00000549273 | ENST00000506690 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| intron-intron | ENST00000549273 | ENST00000389805 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| intron-intron | ENST00000549273 | ENST00000402874 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| intron-intron | ENST00000549273 | ENST00000510187 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
| intron-intron | ENST00000549273 | ENST00000360718 | RPL18 | chr19 | 49118588 | - | SQSTM1 | chr5 | 179250858 | + |
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FusionProtFeatures for RPL18_SQSTM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPL18 | SQSTM1 |