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Fusion gene ID: 31744 |
FusionGeneSummary for RPAP1_IGF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RPAP1_IGF2 | Fusion gene ID: 31744 | Hgene | Tgene | Gene symbol | RPAP1 | IGF2 | Gene ID | 26015 | 3481 |
| Gene name | RNA polymerase II associated protein 1 | insulin like growth factor 2 | |
| Synonyms | - | C11orf43|GRDF|IGF-II|PP9974 | |
| Cytomap | 15q15.1 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA polymerase II-associated protein 1 | insulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptin | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9BWH6 | P01344 | |
| Ensembl transtripts involved in fusion gene | ENST00000561603, ENST00000304330, ENST00000568413, | ENST00000381395, ENST00000381406, ENST00000416167, ENST00000300632, ENST00000434045, ENST00000381392, ENST00000381389, ENST00000418738, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 23 X 24 X 8=4416 |
| # samples | 4 | 20 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/4416*10)=-4.46466826700344 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RPAP1 [Title/Abstract] AND IGF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IGF2 | GO:0008284 | positive regulation of cell proliferation | 28873464 |
| Tgene | IGF2 | GO:0042104 | positive regulation of activated T cell proliferation | 15694994 |
| Tgene | IGF2 | GO:0043410 | positive regulation of MAPK cascade | 11500939 |
| Tgene | IGF2 | GO:0045840 | positive regulation of mitotic nuclear division | 11500939 |
| Tgene | IGF2 | GO:0046628 | positive regulation of insulin receptor signaling pathway | 11500939 |
| Tgene | IGF2 | GO:0051897 | positive regulation of protein kinase B signaling | 11500939 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE299934 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000561603 | ENST00000381395 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000561603 | ENST00000381406 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-5UTR | ENST00000561603 | ENST00000416167 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000561603 | ENST00000300632 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000561603 | ENST00000434045 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000561603 | ENST00000381392 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000561603 | ENST00000381389 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000561603 | ENST00000418738 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000304330 | ENST00000381395 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000304330 | ENST00000381406 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-5UTR | ENST00000304330 | ENST00000416167 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000304330 | ENST00000300632 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000304330 | ENST00000434045 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000304330 | ENST00000381392 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000304330 | ENST00000381389 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000304330 | ENST00000418738 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000568413 | ENST00000381395 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000568413 | ENST00000381406 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-5UTR | ENST00000568413 | ENST00000416167 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000568413 | ENST00000300632 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000568413 | ENST00000434045 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000568413 | ENST00000381392 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000568413 | ENST00000381389 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
| intron-intron | ENST00000568413 | ENST00000418738 | RPAP1 | chr15 | 41829164 | - | IGF2 | chr11 | 2160391 | - |
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FusionProtFeatures for RPAP1_IGF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RPAP1 | IGF2 |