|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 317 |
FusionGeneSummary for ACACA_PARD6G |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACACA_PARD6G | Fusion gene ID: 317 | Hgene | Tgene | Gene symbol | ACACA | PARD6G | Gene ID | 31 | 84552 |
| Gene name | acetyl-CoA carboxylase alpha | par-6 family cell polarity regulator gamma | |
| Synonyms | ACAC|ACACAD|ACC|ACC1|ACCA | PAR-6G|PAR6gamma | |
| Cytomap | 17q12 | 18q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alpha | partitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gamma | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q13085 | Q9BYG4 | |
| Ensembl transtripts involved in fusion gene | ENST00000353139, ENST00000360679, ENST00000394406, ENST00000335166, ENST00000416895, ENST00000361253, ENST00000588142, ENST00000589665, | ENST00000353265, ENST00000470488, | |
| Fusion gene scores | * DoF score | 23 X 13 X 11=3289 | 7 X 2 X 7=98 |
| # samples | 21 | 7 | |
| ** MAII score | log2(21/3289*10)=-3.96918777516928 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACACA [Title/Abstract] AND PARD6G [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-X6-A7W8-01A | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000353139 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000353139 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000360679 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000360679 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| 5UTR-3CDS | ENST00000394406 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| 5UTR-3CDS | ENST00000394406 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000335166 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000335166 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000416895 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000416895 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000361253 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000361253 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000588142 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000588142 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000589665 | ENST00000353265 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
| intron-3CDS | ENST00000589665 | ENST00000470488 | ACACA | chr17 | 35715942 | - | PARD6G | chr18 | 77960815 | - |
Top |
FusionProtFeatures for ACACA_PARD6G |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACACA | PARD6G |