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Fusion gene ID: 31695 |
FusionGeneSummary for ROCK2_ASAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROCK2_ASAP2 | Fusion gene ID: 31695 | Hgene | Tgene | Gene symbol | ROCK2 | ASAP2 | Gene ID | 9475 | 8853 |
| Gene name | Rho associated coiled-coil containing protein kinase 2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | |
| Synonyms | ROCK-II | AMAP2|CENTB3|DDEF2|PAG3|PAP|Pap-alpha|SHAG1 | |
| Cytomap | 2p25.1 | 2p25.1|2p24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2PYK2 C terminus-associated proteincentaurin, beta 3development and differentiation-enhancing factor 2paxillin-associated protein with ARF GAP activity 3pyk2 C-terminus-associated p | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | O75116 | O43150 | |
| Ensembl transtripts involved in fusion gene | ENST00000315872, ENST00000462366, ENST00000401753, | ENST00000281419, ENST00000315273, ENST00000491413, | |
| Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 3 X 3 X 3=27 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/27*10)=0.888968687611256 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ROCK2 [Title/Abstract] AND ASAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK2 | GO:0006468 | protein phosphorylation | 18559669 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-HU-A4GU-01A | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000315872 | ENST00000281419 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| In-frame | ENST00000315872 | ENST00000315273 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| 5CDS-intron | ENST00000315872 | ENST00000491413 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| intron-3CDS | ENST00000462366 | ENST00000281419 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| intron-3CDS | ENST00000462366 | ENST00000315273 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| intron-intron | ENST00000462366 | ENST00000491413 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| Frame-shift | ENST00000401753 | ENST00000281419 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| Frame-shift | ENST00000401753 | ENST00000315273 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
| 5CDS-intron | ENST00000401753 | ENST00000491413 | ROCK2 | chr2 | 11338617 | - | ASAP2 | chr2 | 9419446 | + |
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FusionProtFeatures for ROCK2_ASAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROCK2 | ASAP2 |