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Fusion gene ID: 31681 |
FusionGeneSummary for ROCK1_CIDEA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROCK1_CIDEA | Fusion gene ID: 31681 | Hgene | Tgene | Gene symbol | ROCK1 | CIDEA | Gene ID | 6093 | 1149 |
| Gene name | Rho associated coiled-coil containing protein kinase 1 | cell death-inducing DFFA-like effector a | |
| Synonyms | P160ROCK|ROCK-I | CIDE-A | |
| Cytomap | 18q11.1 | 18p11.21|18 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35 | cell death activator CIDE-A | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13464 | O60543 | |
| Ensembl transtripts involved in fusion gene | ENST00000399799, | ENST00000320477, ENST00000521296, | |
| Fusion gene scores | * DoF score | 21 X 11 X 11=2541 | 2 X 2 X 2=8 |
| # samples | 23 | 2 | |
| ** MAII score | log2(23/2541*10)=-3.46569060910898 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ROCK1 [Title/Abstract] AND CIDEA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROCK1 | GO:0007159 | leukocyte cell-cell adhesion | 12082081 |
| Hgene | ROCK1 | GO:0022614 | membrane to membrane docking | 12082081 |
| Hgene | ROCK1 | GO:0032091 | negative regulation of protein binding | 18573880 |
| Hgene | ROCK1 | GO:0032956 | regulation of actin cytoskeleton organization | 25911094 |
| Hgene | ROCK1 | GO:0050900 | leukocyte migration | 12082081 |
| Hgene | ROCK1 | GO:0050901 | leukocyte tethering or rolling | 12082081 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-L5-A8NE-01A | ROCK1 | chr18 | 18691436 | - | CIDEA | chr18 | 12262824 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000399799 | ENST00000320477 | ROCK1 | chr18 | 18691436 | - | CIDEA | chr18 | 12262824 | + |
| intron-3UTR | ENST00000399799 | ENST00000521296 | ROCK1 | chr18 | 18691436 | - | CIDEA | chr18 | 12262824 | + |
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FusionProtFeatures for ROCK1_CIDEA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROCK1 | CIDEA |