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Fusion gene ID: 31657 |
FusionGeneSummary for ROBO1_HECW2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ROBO1_HECW2 | Fusion gene ID: 31657 | Hgene | Tgene | Gene symbol | ROBO1 | HECW2 | Gene ID | 6091 | 57520 |
| Gene name | roundabout guidance receptor 1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | |
| Synonyms | DUTT1|SAX3 | NDHSAL|NEDL2 | |
| Cytomap | 3p12.3 | 2q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | roundabout homolog 1deleted in U twenty twentyroundabout, axon guidance receptor, homolog 1 | E3 ubiquitin-protein ligase HECW2HECT-type E3 ubiquitin transferase HECW2NEDD4-like E3 ubiquitin-protein ligase 2NEDD4-related E3 ubiquitin ligase NEDL2 | |
| Modification date | 20180519 | 20180526 | |
| UniProtAcc | Q9Y6N7 | Q9P2P5 | |
| Ensembl transtripts involved in fusion gene | ENST00000464233, ENST00000436010, ENST00000495273, ENST00000467549, ENST00000466906, | ENST00000260983, ENST00000409111, | |
| Fusion gene scores | * DoF score | 11 X 11 X 5=605 | 5 X 4 X 4=80 |
| # samples | 11 | 5 | |
| ** MAII score | log2(11/605*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ROBO1 [Title/Abstract] AND HECW2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ROBO1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 12504588 |
| Hgene | ROBO1 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration | 15207848 |
| Hgene | ROBO1 | GO:0050772 | positive regulation of axonogenesis | 12504588 |
| Hgene | ROBO1 | GO:0050925 | negative regulation of negative chemotaxis | 11748139 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A7-A26F-01A | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000464233 | ENST00000260983 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| intron-3CDS | ENST00000464233 | ENST00000409111 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| Frame-shift | ENST00000436010 | ENST00000260983 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| Frame-shift | ENST00000436010 | ENST00000409111 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| Frame-shift | ENST00000495273 | ENST00000260983 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| Frame-shift | ENST00000495273 | ENST00000409111 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| Frame-shift | ENST00000467549 | ENST00000260983 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| Frame-shift | ENST00000467549 | ENST00000409111 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| intron-3CDS | ENST00000466906 | ENST00000260983 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
| intron-3CDS | ENST00000466906 | ENST00000409111 | ROBO1 | chr3 | 79067557 | - | HECW2 | chr2 | 197106928 | - |
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FusionProtFeatures for ROBO1_HECW2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ROBO1 | HECW2 |