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Fusion gene ID: 3165

FusionGeneSummary for ATG13_MYO15B

Fusion gene summary

Fusion gene information	Fusion gene name: ATG13_MYO15B
	Fusion gene ID: 3165
		Hgene	Tgene
	Gene symbol	ATG13	MYO15B
	Gene ID	9776	80022
	Gene name	autophagy related 13	myosin XVB
	Synonyms	KIAA0652\|PARATARG8	MYO15BP
	Cytomap	11p11.2	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	autophagy-related protein 13ATG13 autophagy related 13 homolog	myosin XVBmyosin XVB pseudogeneunconventional myosin XVBP pseudogene
	Modification date	20180523	20180519
	UniProtAcc	O75143	Q96JP2
	Ensembl transtripts involved in fusion gene	ENST00000434074, ENST00000312040, ENST00000451945, ENST00000529655, ENST00000530500, ENST00000526508, ENST00000524625, ENST00000359513, ENST00000528494, ENST00000526485,	ENST00000578382, ENST00000583560,
Fusion gene scores	* DoF score	8 X 7 X 5=280	6 X 5 X 5=150
	# samples	10	6
	** MAII score	log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATG13 [Title/Abstract] AND MYO15B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA345253	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000434074	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-intron	ENST00000434074	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-3UTR	ENST00000312040	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-intron	ENST00000312040	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-3UTR	ENST00000451945	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-intron	ENST00000451945	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-3UTR	ENST00000529655	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-intron	ENST00000529655	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-3UTR	ENST00000530500	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-intron	ENST00000530500	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-3UTR	ENST00000526508	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-intron	ENST00000526508	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-3UTR	ENST00000524625	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-intron	ENST00000524625	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-3UTR	ENST00000359513	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
3UTR-intron	ENST00000359513	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-3UTR	ENST00000528494	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-intron	ENST00000528494	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-3UTR	ENST00000526485	ENST00000578382	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+
intron-intron	ENST00000526485	ENST00000583560	ATG13	chr11	46694853	+	MYO15B	chr17	73608897	+

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FusionProtFeatures for ATG13_MYO15B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATG13 O75143	MYO15B Q96JP2

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Fusion gene ID: 3165

FusionGeneSummary for ATG13_MYO15B

FusionProtFeatures for ATG13_MYO15B